乳果糖联合匹维溴铵、双歧三联活菌和氟西汀治疗肠易激综合征便秘型患者的临床效果

Clinical effect of lactulose combined with pinaverium bromide,Bifidobacterium triplex and fluoxetine in the treatment of constipation type patients of irritable bowel syndrome

目的探究乳果糖联合匹维溴铵、双歧三联活菌、氟西汀治疗肠易激综合征便秘型(IBS-C)患者的临床效果。方法选择2015年11月至2019年11月本院收治的230例IBS-C患者进行研究,根据治疗方式不同将其分成对照组和观察组,每组115例。对照组采取匹维溴铵、双歧三联活菌、氟西汀治疗,观察组在对照组基础上给予乳果糖进行治疗。比较两组患者临床疗效、不良反应发生情况、复发率、治疗满意度及治疗前、后临床症状评分。结果观察组治疗总有效率为97.39%,高于对照组的90.43%(P<0.05)。观察组不良反应总发生率高于对照组,但差异无统计学意义(P>0.05);观察复发率低于对照组(P<0.05)。观察组治疗满意度评分高于对照组(P<0.05)。治疗后,观察组各临床症状评分均低于对照组(P<0.05)。结论 IBS-C患者采用乳果糖联合匹维溴铵、双歧三联活菌、氟西汀治疗能提高临床治疗效果和患者治疗满意度,改善患者病情,值得推荐。

Objective To investigate the clinical effect of lactulose combined with pinaverium bromide,Bifidobacterium triplex and fluoxetine in the treatment of constipation type patients of irritable bowel syndrome(IBS-C).Methods From November 2015 to November 2019,230 patients with IBS-C admitted in our hospital were selected for study.According to different treatment methods,the patients were divided into control group and observation group,with 115 cases in each group.The control group was treated with pinaverium bromide,Bifidobacterium triplex and fluoxetine,while the observation group was treated with lactulose on the basis of the control group.The clinical efficacy,adverse reactions,recurrence rate,treatment satisfaction and clinical symptoms score before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.39%,which was higher than 90.43%in the control group(P<0.05).The total incidence of adverse reactions in the observation group was higher than that in the control group,but the difference was not statistically significant(P>0.05);the recurrence rate in the observation group was lower than that in the control group(P<0.05).The treatment satisfaction score in the observation group was higher than that in the control group(P<0.05).After treatment,the clinical symptom scores in the observation group were lower than those in the control group(P<0.05).Conclusion Lactulose combined with pinaverium bromide,Bifidobacterium triplex and fluoxetine can improve the clinical treatment effect of IBS-C patients and the patients'treatment satisfaction,and improve the disease condition of patients,which is worth recommending.