免疫球蛋白检验在慢性乙型肝炎患者中的应用价值

Application value of immunoglobulin test in patients with chronic hepatitis B

目的探究免疫球蛋白检验在慢性乙型肝炎患者中的应用价值。方法将2017年1月至2018年12月的400例慢性乙型肝炎患者设为试验组,同时选取400例健康体检者设为对照组。比较两组受检者的免疫球蛋白、总蛋白、白蛋白、ALT、GGT、AST、TBIL水平;比较轻度乙肝、中度乙肝、重度乙肝患者免疫球蛋白、ALT、GGT、AST、TBIL水平。结果试验组的IgG、IgA、IgM水平均显著高于对照组(P<0.05);试验组的总蛋白、白蛋白水平显著低于对照组(P<0.05)。试验组的ALT、GGT、AST、TBIL水平显著高于对照组(P<0.05)。中度乙肝、重度乙肝患者的IgG、IgA、IgM、ALT、GGT、AST、TBIL水平高于轻度乙肝患者,且重度乙肝患者高于中度乙肝患者(P<0.05)。结论免疫球蛋白检验能够反映慢性乙型肝炎患者的病情严重程度,可作为疾病确诊的辅助参考依据。

Objective To explore the application value of immunoglobulin test in patients with chronic hepatitis B.Methods From January 2017 to December 2018,400 patients with chronic hepatitis B were set as experimental group,while 400 healthy people were selected and set as control group.The levels of immunoglobulin,total protein,albumin,ALT,GGT,AST and TBIL were compared between the two groups;the levels of immunoglobulin,ALT,GGT,AST and TBIL in patients with mild,moderate and severe hepatitis B were compared.Results The levels of IgG,IgA and IgM in the experimental group were significantly higher than those in the control group(P<0.05);the levels of total protein and albumin in the experimental group were significantly lower than those in the control group(P<0.05).The levels of ALT,GGT,AST and TBIL of the experimental group were significantly higher than those of the control group(P<0.05).The levels of IgG,IgA,IgM,ALT,GGT,AST and TBIL in patients with moderate and severe hepatitis B were higher than those in patients with mild hepatitis B,and those in patients with severe hepatitis B were higher than those in patients with moderate hepatitis B(P<0.05).Conclusion Immunoglobulin test can reflect the severity of chronic hepatitis B patients,and can be used as an auxiliary reference for disease diagnosis.