丹参多酚酸对小动脉闭塞性脑梗死患者认知功能的影响

Effect of salvia miltiorrhiza polyphenolic acid on cognitive impairment of patients with ischemic stroke of small artery occlusion.

目的观察丹参多酚酸对小动脉闭塞性脑梗死患者认知功能的影响。方法选取2016年7月至2018年3月于晋城市人民医院住院的认知功能减退患者73例,均为TOAST分型中小动脉闭塞性脑梗死者。依据随机数字表分为对照组38例与观察组35例。对照组给予脑梗死常规治疗,观察组在对照组的基础上增加丹参多酚酸100 mg静脉滴注,每天1次,共治疗14 d。在治疗前及治疗后1、3、6个月分别对研究对象进行蒙特利尔认知评估量表(MoCA)、简易精神状态检查量表(MMSE)评分。结果治疗前两组MoCA、MMSE评分比较差异未见统计学意义(P>0.05)。治疗后两组在各时间点评分均较治疗前增加,治疗后1、3个月,组间评分比较差异未见统计学意义(P>0.05),治疗后6个月观察组较对照组评分显著改善(P<0.05)。结论丹参多酚酸可以改善小动脉闭塞性脑梗死所致患者认知功能减退。

Objective To observe the effects of salvia miltiorrhiza polyphenolic acid on cognitive impairment of patients with ischemic stroke of small artery occlusion.Methods A total of 73 patients from July 2016 to March 2018 who met the criteria of TOAST classification of arteriolus occlusive cerebral infarction and had objective cognitive impairment related to small arteriolus occlusive cerebral infarction were seleted.The random number table was used to divide the control group(38 cases)and the observation group(35 cases).The control group was given conventional cerebral infarction treatment while the observation group was treated with 100 mg of salvia miltiorrhiza polyphenolic acid by intravenous drip once a day on the basis of conventional treatment for 14 days.The subjects were given the Montreal Cognitive Assessment(MoCA)and Mini-Mental State Examination(MMSE)score before the treatment and one month,three months and six months after the treatment.Results There was no significant defference in MMSE and MoCA scores between the two groups before the treatment(P>0.05).After the treatment,the scores of different time point in the two groups were higher than those before the treatment.In the first month and the three months after the treatment,there was no significant difference between the two groups(P>0.05),and the scores of the observation group were significantly higher than those of the control group at 6 months after the treatment(P<0.05).Conclusions Salvia miltiorrhiza polyphenolic acid can reduce cognitive impairment caused by small artery occlusion.