注射用益气复脉联合冻干重组人脑利钠肽辅助治疗老年慢性心力衰竭急性发作的效果

Effects of yiqi fumai injection and lyophilized recombinant human brain natriuretic peptide on elderly patients with acute exacerbation of chronic heart failure

目的探讨注射用益气复脉联合冻干重组人脑利钠肽(rhBNP)辅助治疗老年慢性心力衰竭(CHF)急性发作的效果。方法抽取山西中医学院附属医院2017年6月至2019年6月78例老年CHF急性发作期患者作为分析对象,按照随机数字表法将其分为观察组与对照组,每组39例。两组患者均予西医标准抗心衰治疗,对照组患者在西医标准治疗基础上联合使用rhBNP,观察组患者在对照组基础上联合使用注射用益气复脉治疗,疗程均为1周。1周后统计分析两组患者治疗前后的中医证候积分、N端脑钠肽前体(NT-proBNP)、单核细胞趋化因子-1(MCP-1)、肿瘤坏死因子(TNF-α)及生活质量,比较两组患者临床疗效。结果观察组患者临床总有效率高于对照组(P<0.05)。治疗1周后,两组患者中医证候积分低于治疗前,且观察组低于对照组(P<0.05);两组患者的NT-proBNP、MCP-1、TNF-α水平较治疗前明显降低,且观察组低于对照组(P均<0.05);两组患者生活质量评分均低于治疗前,且观察组低于对照组(P均<0.05)。结论注射用益气复脉与rhBNP治疗老年CHF急性发作疗效显著,能有效改善患者临床症状及心功能。

Objective To investigate the effects of yiqi fumai injection and lyophilized recombinant human brain natriuretic peptide(rhBNP)on elderly patients with acute exacerbation of chronic heart failure(CHF).Methods A total of 78 elderly patients with acute exacerbation of CHF who were treated and diagnosed in Affiliated Hospital of Shanxi College of Traditional Chinese Medicine from June 2017 to June 2019 were selected as the analysis subjects,and they were divided into observation group and control group according to the random number table method,with 39 cases in each group.Patients in the two groups were given standard western medicine anti-heart failure treatment,and patients in control group were combined with rhBNP based on the standard western medicine treatment while patients in observation group were combined with yiqi fumai injection on the basis of control group,and the two groups were treated for 1 week.The scores of TCM syndromes,N-terminal pro-brain natriuretic peptide(NT-proBNP),monocyte chemoattractant protein(MCP-1),tumor necrosis factor(TNF-α)and quality of life before and after treatment were counted and analyzed in the two groups after 1 week.The clinical efficacy of the two groups was compared.Results The total clinical effective rate in observation group was significantly higher than that in control group(P<0.05).After 1 week of treatment,the TCM syndromes scores in the two groups were lower than those before treatment,and the scores in observation group were significantly lower than those in control group(P<0.05).The levels of NT-proBNP,MCP-1 and TNF-αin the two groups were significantly decreased compared with those before treatment,and the levels in observation group were lower than those in control group(P<0.05).The quality of life scores in the two groups were lower than those before treatment,and the score in observation group was lower than that in control group(all P<0.05).Conclusions Yiqi fumai injection and rhBNP can have significant efficacy on elderly patients with acute exacerbation of CHF,and can effectively improve the clinical symptoms and cardiac function of patients.