摘要
In the past decade,nanoscale metal-organic frameworks(nMOFs)have drawn a great attention due to their high porosity,wide range of pore shapes,tunable frameworks and relatively low toxic.With the development of nanotechnology,many researchers studied the synthesis,characterization,functionalization and biotoxicity of nMOFs,and a more thorough understanding was developed about numerous nMOFs as promising platforms for biomedical applications.This review highlights the up-to-date progress of nMOFs related to their bio-applications such as drug delivery,bioimaging,biosensing and biocatalysis,and the common surface modification methods we re classified into four categories:covalent post-synthetically modification,coordinative post-synthetically modification,noncovalent postsynthetically modification and modification on the external surface.At the same time,the challenges and perspectives of nMOFs were discussed as well.
基金
supported by the National Natural Science Foundation of China(Nos.81970985,81771122,81601613,21501123)
Science&Technology Support Program of Sichuan Province(Nos.2018SZ0037,19YYJC2625)
the Graduate Student’s Research and Innovation Fund of Sichuan University(No.2018YJSY108)
the China Postdoctoral Science Foundation Funded Project(No.2018M640931)
the Science&Technology Key Research and Development Program of Sichuan Province(No.2019YFS0142)。
