摘要
(+)-6-3’a,7-6’-Isowallichilide and(-)-6-3’a,7-6’-isowallichilide,a pair of enantio meric phthalide dimers featuring new 6-3’a,7-6’dimerization sites,were isolated from Ligusticum chuanxiong.The structures were elucidated by NMR spectroscopy and X-ray diffraction analysis.Furthermore,the absolute configurations were assigned using experimental and theoretical electronic circular dichroism methods.Their nitric oxide inhibition,antiplatelet aggregation and antioxidant activities were investigated.
基金
supported by the Shanghai Municipal Commission of Health and Family Planning(No.ZY3-CCCX-3-5001)
the Science and Technology Commission of Shanghai Municipality(Nos.14401901400,15DZ2292000)
the Expenditure Budget Program of Shanghai Municipal Education Commission(No.2016YSN24)
Xinglin Young Talent Program of Shanghai University of Traditional Chinese Medicine。
