摘要
An efficient method was developed for the conjugate addition of water to various a,β-unsaturated ketones by using bismuth(Ⅲ)chlo ride as a catalyst.The reactions proceeded smoothly in the presence of a catalytic amount of BiCl3(20 mol%)in aqueous media to furnish a variety of synthetically usefulβ-hydroxyl ketones in moderate to good yields.Apart from water molecule,various alcohols could also be employed as nucleophiles to react withα,β-unsaturated ketones,leading toβ-alkoxyl ketones in modest to high yields.In addition,the mild reaction conditions also entailed the conjugate addition reactions to proceed with the tolerance to a range of functional groups.
基金
financial support from Nanjing Tech University(Start-up Grant No.39837118)
Yancheng Teachers University,and Nanjing Forestry University。
