摘要
An efficient gold-catalyzed anti-Markovnikov cycloisomerization-initiated tandem reaction of Bocprotected indole tethered homopropargyl amides has been achieved.This method delivers a wide range of valuable bridged aza-[n.2.1]skeletons(n=3-7)at room temperature with high diastereoselectivity and enantioselectivity by a chirality-transfer strategy.Moreover,the gold-catalyzed tandem reaction of homopropargyl alcohol is also achieved to produce the bridged oxa-[3.2.1]skeleton.
基金
financial support from the National Natural Science Foundation of China(Nos.21622204,21572186,21772161,21572163 and 21372178)
the Natural Science Foundation of Fujian Province of China(No.2019J02001)
the President Research Funds from Xiamen University(No.20720180036)
NFFTBS(No.J1310024)
PCSIRT
Science&Technology Cooperation Program of Xiamen(No.3502Z20183015)。
