血府逐瘀胶囊对ICVD介入术后血栓弹力图、血管内皮功能及复发缺血事件的影响

Effect of Xuefu Zhuyu Capsule on Thrombotic Elastic Diagram,Vascular Endothelial Function and Recurrent Ischemic Events after Interventional Treatment of Ischemic Cerebrovascular Disease

目的探讨血府逐瘀胶囊对缺血性脑血管病(ICVD)介入术后血栓弹力图、血管内皮功能及复发性缺血事件的影响.方法接受治疗的162例ICVD患者应用随机数表法将其分为对照组、研究组,每组81例.对照组患者接受单纯介入治疗,研究组患者接受介入手术+术后血府逐瘀胶囊治疗.持续治疗6个月后,对比两组患者的血栓弹力图参数(血凝块形成时间(R)、血凝块稳定时间(K)、血凝块最大强度(MA)、血凝块形成曲线角度(A))、血管内皮功能指标(内皮素-1(EF-1)、一氧化氮(NO)、血管性血友病因子(v WF)、可溶性细胞间黏附分子-1(s ICAMs-1)、可溶性P选择素(s P-selectin))水平的差异,记录复发性缺血事件及药物相关不良反应的发生情况.结果介入术后6个月,研究组患者的R、K水平大于对照组,MA、A水平低于对照组;血清中EF-1、v WF、s ICAMs-1、s P-selectin水平小于对照组,NO水平大于对照组(P<0.05).随访期内,研究组患者的复发性缺血事件发生率低于对照组(P<0.05),两组患者服药期间无一例发生明显药物相关不良反应.结论 ICVD患者介入术后接受血府逐瘀胶囊治疗可明显改善凝血功能及血管内皮功能,减少复发性缺血事件的发生,可能是ICVD治疗的理想药物之一.

Objective To investigate the effect of Xuefu Zhuyu capsule on thrombotic elastic diagram,vascular endothelial function and recurrent ischemic events after interventional treatment of ischemic cerebrovascular disease.Method 162 cases of ICVD underwent interventional therapy were divided into control group and study group by random number table method,each with 81 cases.Patients in control group underwent simple interventional therapy,while those in study group underwent interventional surgery+postoperative Xuefu Zhuyu capsule.After 6 months treatment,thrombus elastic graph parameters of two groups(blood clot formation(R),blood clots,stability time(K),blood clots,maximum intensity(MA),blood clots form curve Angle(A)),endothelial function indexes(endothelin-1(EF),nitric oxide(NO),von willebrand factor(vWF)and soluble intercellular adhesion molecule-1(sICAMs-1),choice of soluble P element(sP-selectin))levels difference were compared between two groups,recurrent ischemic events and drug related adverse reaction were recorded.Results After 6 months intervention,R and K levels in study group were higher than those in control group,MA and A levels in study group were lower than those in control group;levels of EF-1,vWF,sICAMs-1 and sP-selectin were lower than those in control group,level of NO was higher than that in control group(P<0.05).During the follow-up period,incidence of recurrent ischemic events in study group was lower than that in control group(P<0.05).No significant drug-related adverse reactions occurred in either group.Conclusion Xuefu Zhuyu capsule after ICVD can improve coagulation function and vascular endothelial function,and play an active role in reducing recurrent ischemic events,which may be one of the ideal drugs for ICVD treatment.