前景可观的senolytics延缓衰老的研究进展

The progress of promising senolytics in delaying senescence

细胞衰老呈现不可逆的永久性细胞周期停滞的状态,它可以促进组织在发育过程中和损伤后的重塑,但也会导致老年生物体组织再生潜力和功能的下降,以及炎症和肿瘤的发生。研究发现,清除衰老细胞可以延缓衰老相关疾病的发生。因此,探究衰老细胞的分子特征与探索清除衰老细胞的新药成为衰老研究领域的热点。近年来,人们发现一类称为senolytics的小分子化合物能特异性靶向衰老细胞并帮助清除衰老细胞,从而延长哺乳动物的寿命及健康寿命。该文对衰老细胞的分子特征、作为衰老相关疾病的治疗靶点及具有senolytics活性的化合物作用机制和潜在应用进行了综述。

Cellular senescence exhibits the irreversible and permanent state of cell cycle arrest, which can promote tissue remodeling during development and after injury, but can also lead to decreased tissue regenerative potential and function, inflammation and tumorigenesis in aged organisms. Studies have shown that the elimination of senescent cells can delay occurrence of aging-related diseases. Therefore, characterization and drug-based clearance of senescent cells have become the focus in the field of aging research. In recent years, small molecular compounds called senolytics have been found to specifically target senescent cells, thus prolonging the lifespan and healthspan of mammals. In this review, we discussed the molecular characteristics of senescent cells, targeting senescent cells as therapeutic strategy for aging-related diseases and the compounds with senolytics activity and their related mechanisms.