JNK信号通路与纤维化疾病

JNK signaling pathway in fibrotic disease

c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)是丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)家族中的重要一员,JNK信号通路是MAPK三大主要信号通路之一。JNK信号通路激活可促进肺、心、肝及肾等多种器官的纤维化过程。本文对近年来JNK信号通路在纤维化疾病中的研究进展进行了综述,为纤维化疾病的治疗提供了新思路。

c-Jun N-terminal kinase(JNK)is an important member of mitogen-activated protein kinase(MAPK)family.JNK signaling pathway is one of the three major signaling pathways of MAPK.Activation of JNK signaling pathway can promote fibrosis in lung,heart,liver,kidney and other organs.This review summarized the recent progress of JNK signaling pathway in fibrotic disease and provided new strategies for the treatment of fibrosis disease.