VitD调控Wnt信号通路影响糖尿病心血管并发症的研究进展

Research progress of VitD on cardiovascular complications of diabetes via Wnt signaling pathway

糖尿病心血管并发症是糖尿病致死的首要原因。近期研究发现维生素D(Vitamin D,VitD)缺乏与2型糖尿病及其心血管并发症之间存在一定的联系。VitD结合维生素D受体(Vitamin D receptor,VDR)发挥一系列生物学效应,其中VDR可通过多种途径抑制β连环蛋白(β-catenin)从而调控经典Wnt信号通路,而Wnt信号通路可从多方面促进糖尿病各种心血管并发症的发生。为阐明三者之间的关系,本文就VitD调控Wnt/β-catenin信号通路影响糖尿病心血管并发症的相关研究进行系统回顾,以期为糖尿病心血管并发症的防治提供新思路。

Cardiovascular complications of diabetes are the leading cause of death from diabetes.Recent studies have found a relationship between Vitamin D(VitD)deficiency and type 2 diabetes mellitus(T2DM)and its cardiovascular complications.VitD binds to Vitamin D receptor(VDR)to exert a series of biological effects.VDR can inhibitβ-catenin to regulate the classic Wnt signaling pathway,which can promote the occurrence of various cardiovascular complications of diabetes.This review intends to systematically summerize the related research on the influence of VitD on the cardiovascular complications of diabetes through regulating the Wnt/β-catenin signaling pathway,in order to explain the relationship between them,so as to provide new ideas for the prevention and treatment of cardiovascular complications of diabetes.