自体脂肪移植中供体因素对脂肪来源干细胞生物学功能影响的研究进展

An update about the donor effect on the biological function of adipose-derived stem cells in autologous fat grafting

自体脂肪移植被广泛应用于面部年轻化、胸部塑形以及身体各部位软组织凹陷的填充、创面及瘢痕的防治。然而,脂肪移植后的临床效果并不稳定。当前,大量的研究集中在脂肪组织的获取、提纯、注射和移植后的再生机制等领域,鲜有文献系统地总结供体因素对脂肪移植临床效果的影响。该文就脂肪来源干细胞(adipose-derived stem cells,ASCs)的作用机制、供体因素对脂肪组织和ASCs生物学功能的影响进行了综述,为进一步稳定脂肪移植的临床效果提供参考。

Autologous fat grafting is widely used in facial rejuvenation,breast shaping,correction of body depression,and repair of wounds and scars.However,the therapeutic effect of fat grafting is not always stable.At present,plenty of study is focused on the harvest,purification,injection and post-transplantation regeneration mechanism of adipose tissue,while the effect of the donor factor on therapeutic result of fat grafting is rarely systematically summarized.Therefore,the mechanism of adipose-derived stem cells(ASCs)and the effect of the donor on biological function of adipose tissue and ASCs are reviewed in this article,so as to provide a reference for further stable result of fat grafting.