亚欧地区部分国家队列研究进展分析

Progress of cohort studies in countries from Asia and Europe

目的梳理西亚地区17个国家和中东欧地区16个国家队列研究概况,分析典型前瞻性自然人群队列的分布、建设及发展状况。方法采用文献回顾法收集队列研究的基本信息,采用描述性研究方法分析队列研究的特征。结果西亚和中东欧地区各国共有样本量在1000人及以上的队列研究562项,国家内队列研究468项(83.27%),国际多中心队列研究94项(16.73%);从研究性质来看,病因学研究347项(61.74%);从研究内容来看,慢性非传染性疾病研究310项(55.16%),母婴健康研究125项(22.24%),其中,慢性非传染性疾病研究中,癌症研究51项(16.45%),心血管疾病研究83项(26.77%);共有大型前瞻性自然人群队列研究10项,主要分布在伊朗和欧洲地区各国,均为在研项目,持续时间在8~29年之间,队列规模>50000人的4项;从建立机制看,均进行流行病学调查、健康体检和生物样本收集;从队列发展来看,10项队列研究中有9项在建设初期发表文章较少,随后逐年增长并保持在一定水平上下波动。结论西亚和中东欧地区各国队列研究地区分布不平衡,主要进行病因学研究,重点关注癌症、心血管疾病、糖尿病、呼吸系统疾病、精神心理疾病等慢性非传染性疾病和母婴健康,具有少数可供借鉴的大型前瞻性自然人群队列。

Objective To share related knowledge and experiences with countries along the line,literature regarding current cohort studies was summarized.Distribution,establishment and development of cohort studies among large prospective general population were analyzed in 17 countries of Western Asia and the 16 countries of Central and Eastern Europe.Methods Literature review was conducted to collect basic information on cohort studies,with descriptive study used to analyze the characteristics of these cohort studies.Results There were 562 cohort studies with sample size as more than 1000 stated in Western Asia and Central and Eastern Europe,including 468(83.27%)carried out in the nation itself and 94(16.73%)with international multicentered collaboration.According to the nature of cohort studies,347(61.74%)were etiologically based.As for the contents involved,310(55.16%)of them targeted on chronic/non-communicable diseases,125(22.24%)concentrated on maternal and child health.Among those on chronic/non-communicable diseases,51(16.45%)were on cancers and 83(26.77%)on cardiovascular disease studies.There appeared 10 large prospective cohort studies targeting on general population,mainly ongoing in Iran and European countries,with a duration of 8-29 years,including 4 of them with sample size as more than 50000.In terms of the contents,epidemiological investigation,physical examination and biological samples collection took the major parts.Few papers were published in 9 out of the 10 cohort studies at the early stage of those projects but the number of papers increased annually and stabilized to certain extent.Conclusions The regional distribution of cohort studies carried out in countries from the Western Asia and Central and Eastern European areas appeared unbalanced.Contents of these designs would mainly involve etiological studies,with focus on non-communicable diseases as cancer,cardiovascular disease,diabetes,respiratory diseases,mental and psychological diseases,and maternal and infant health etc..However,only few large prospective cohort studies would base on general population.