摘要
TLR4/MD2/NF-κB是细胞内一条重要的信号通路,该通路主要参与脂多糖和软脂酸等刺激信号的识别及转导,既往认为该通路主要与感染性炎症有关;近年研究表明,它与肿瘤、自身免疫性疾病、代谢性疾病等密切相关,靶向TLR4/MD2成为治疗这些疾病的新策略。本文就TLR4/MD2/NF-κB信号通路转导及相关疾病研究进展进行阐述。
TLR4/MD2/NF-κB is an important signal pathway in cells,which is mainly involved in the recognition and transduction of lipopolysaccharide,palmitic acid and other stimulation signals.It was previously believed that this pathway was mainly related to infectious inflammation.Recent studies have shown that TLR4/MD2/NF-κB pathway is closely related to tumors,autoimmune diseases,metabolic diseases and so on.Targeting TLR4/MD2 has become a new strategy for the treatment of these diseases.This article reviews the research advances on TLR4/MD2/NF-κB signaling pathway and related diseases.
作者
宋瑜婷
彭彬
王莹
张雪
曹帆帆
张登海
SONG Yuting;PENG Bin;WANG Ying;ZHANG Xue;CAO Fanfan;ZHANG Denghai(Postgraduate Training Base of Shanghai Pudong New Area Gongli Hospital,Ningxia Medical University,Shanghai 200135,China;Central Laboratory,Gongli Hospital,Navy Medical University,Shanghai 200135,China)
出处
《免疫学杂志》
CAS
CSCD
北大核心
2020年第7期633-638,共6页
Immunological Journal
基金
国家自然科学基金(81400793)
第二军医大学附属公利医院博士后基金(GLBH2017001)
上海市浦东新区卫生和计划生育委员会学科带头人项目(PWRd2018-12)
上海市浦东新区公利医院人才培养计划(GLRb2018-01)
上海市浦东新区公利医院青年英才项目(GLRq2017-01)
上海市浦东新区科技发展基金创新资金(PK2018-Y09)。
关键词
细胞信号转导通路
TLR4
MD2
NF-ΚB
靶向治疗
Cell signal transduction pathway
Toll-like receptor 4
Myeloid differentiation protein 2
NF-kappa B
targeted therapy
