克霉唑阴道片联合乳酸杆菌阴道胶囊对妊娠合并念珠菌性阴道炎患者的疗效

Effect of clotrimazole vaginal tablets combined with lactobacillus vaginal capsules on inflammation and oxidative stress in pregnant women with candidal vaginitis

目的:分析克霉唑阴道片联合乳酸杆菌阴道胶囊对妊娠合并念珠菌性阴道炎患者的疗效。方法:对126例妊娠合并念珠菌性阴道炎患者展开前瞻性研究,简单随机法分为对照组和观察组,均为63例,其中对照组接受克霉唑阴道片治疗,观察组接受克霉唑阴道片联合乳酸杆菌阴道胶囊治疗。观察两组疗效,治疗前后炎性因子水平、氧化应激产物水平及妊娠结局。结果:观察组临床总有效率明显高于对照组(95.24%vs 80.95%,P<0.05)。治疗后,观察组肿瘤坏死因子α、白介素6、C反应蛋白等炎性因子水平均低于对照组(P<0.05),超氧化物歧化酶、一氧化氮水平高于对照组(P<0.05),且丙二醛、血浆内皮素-1水平低于对照组(P<0.05)。观察组早产、胎膜早破发生率明显低于对照组(P<0.05)。结论:克霉唑阴道片联合乳酸杆菌阴道胶囊治疗妊娠合并念珠菌性阴道炎,疗效确切,减轻阴道炎症反应,改善氧化应激状态,减少早产、胎膜早破等不良妊娠结局。

Objective The effect of clotrimazole vaginal tablets combined with lactobacilli vaginal capsules on inflammatory response and oxidative stress in pregnant patients with candidal vaginitis.Methods A prospective study of 126 patients with candidal vaginitis was randomly divided into control group and observation group,63 cases in each group.The control group received clotrimazole vaginal tablets and the observation group received clotrimazole vaginal tablets combined with lactobacillus vaginal capsule treatment.The efficacy,inflammatory factor levels,oxidative stress and pregnancy outcomes of the two groups were observed.Results The total clinical effective rate of the observation group was significantly higher than that of the control group(95.24%vs 80.95%,P<0.05).After treatment,the levels of tumor necrosis factorα,interleukin-6,and C-reactive protein inflammatory factors in the observation group were lower than those in the control group.The levels of superoxide dismutase and nitric oxide in the observation group were higher than those in the control group(P<0.05),and the levels of malondialdehyde and plasma endothelin-1 were lower than those in the control group(P<0.05).The incidence of premature delivery and premature rupture of membranes in the observation group was significantly lower than that in the control group(P<0.05).Conclusions Clotrimazole vaginal tablets combined with lactobacillus vaginal capsules for the treatment of pregnancy with candida vaginitis are effective and can reduce vaginal inflammation,improve oxidative stress,and reduce the occurrence of adverse pregnancy outcomes such as premature delivery and premature rupture of membranes.