脂氧素A4在脑缺血中的抗炎作用

Anti-inflammatory effects of lipoxin A4 in cerebral ischemia

脂氧素A4是花生四烯酸代谢产物之一,是一种可通过多种途径减轻炎症反应的内源性抑炎因子。炎症反应在脑缺血损伤过程中起着重要作用。脂氧素A4可通过调控促炎性细胞因子、保护血脑屏障、抑制白细胞激活和浸润、减轻局部微循环炎症反应、调控白三烯及炎症小体等炎症介质、调节炎症相关酶代谢、减轻氧化应激损伤等多种途径减轻脑缺血损伤过程中的炎症反应,对神经细胞发挥保护作用。文章对脂氧素A4在脑缺血中的抗炎作用进行了综述。

Lipoxin A4(LXA4)is one of the metabolites of arachidonic acid,and it is an endogenous anti-inflammatory factor that can alleviate the inflammatory reaction through various pathways.Inflammatory response plays an important role in the process of cerebral ischemia.LXA4 can play a protective role on nerve cells by regulating proinflammatory cytokines,protecting blood-brain barrier,inhibiting activation and infiltration of leukocyte,alleviating local microcirculation inflammatory response,regulating inflammatory mediators such as leukotrienes and inflammasome,regulating the metabolism of inflammatory related enzymes,and alleviating oxidative stress injury.This article reviews the anti-inflammatory effects of LXA4 in cerebral ischemia.