清肠汤对热盛血瘀型溃疡性结肠炎患者的疗效及对HGF/c-MET表达的影响

Clinical effect of Qingchang decoction on ulcerative colitis patients with heat excess and blood stasis syndrome and its effect on HGF/c-MET expression

[目的]观察清肠汤治疗热盛血瘀型溃疡性结肠炎(UC)患者的临床疗效及其对肝细胞生长因子/肝细胞生长因子受体(HGF/c-MET)表达的影响。[方法]将60例热盛血瘀型UC患者分为治疗组30例,对照组30例,2组均口服美沙拉嗪缓释颗粒,治疗组在美沙拉嗪基础上加用中药清肠汤口服。3个月后对比患者临床症状、临床疗效以及HGF/c-MET表达情况。[结果]治疗组的总有效率为93.33%,优于对照组的70.00%。2组患者治疗前中医症状积分比较差异无统计学意义(P>0.05),治疗后2组积分均有下降,差异有统计学意义(P<0.05),但治疗组在改善腹泻、黏液脓血便、腹痛及总积分方面更为显著,差异有统计学意义(P<0.05)。2组患者结肠黏膜HGF、c-MET免疫组化表达情况进行比较,治疗前2组患者阳性率差异无统计学意义。经治疗后,治疗组HGF阳性率为90.00%,高于对照组的66.67%,差异有统计学意义(P<0.05)。治疗组c-MET的阳性率为93.33%,高于对照组的70.00%,差异有统计学意义(P<0.05)。治疗组不良反应发生率为10.00%,对照组不良反应发生率为6.67%。2组比较差异无统计学意义(P>0.05)。2组患者的不良反应经治疗后均好转。[结论]清肠汤能明显改善患者的临床症状,提高有效率,且安全可靠。其作用机制可能是通过提高HGF/c-MET的表达,修复结肠黏膜,恢复肠上皮屏障功能,从而达到炎症减轻的作用。

[Objective] To observe the clinical effect of Qingchang decoction in treating ulcerative colitis patients with heat excess and blood stasis syndrome and its effect on HGF/c-MET expression.[Methods]Sixty ulcerative colitis patients with heat excess and blood stasis syndrome were divided into treatment group and control group,30 cases per group.Both groups were orally administered mesalazine sustained-release granules.But the treatment group was added Chinese medicine Qingchang decoction more.Three months later,the clinical symptoms,clinical efficacy and HGF/c-MET expression were compared.[Results]Comparison of the comprehensive efficacy of the disease:The total effective rate of the treatment group was 93.33%,which was better than the control group of 70.00%.Comparison of the efficacy of TCM syndromes:TCM symptoms(including diarrhea,mucopurulent bloody stool,abdominal pain and tenesmus)scores and total scores before treatment are not statistically different between the two groups of patients by t test(P>0.05).The total scores are all decreased,and are statistically significant by t test(P<0.05),but the treatment group has more significant effectiveness in improving symptoms(diarrhea,mucopurulent bloody stool,abdominal pain)and total points,the differences are statistically significant(P<0.05).Comparison of colonic mucosal immunohistochemistry between the two groups of patients:There was no significant statistical difference of the positive rate of HGF/c-MET between the two groups before treatment(P<0.05).After treatment,the positive rate of HGF in the treatment group was 90%,which was higher than 66.67% in the control group.The difference was statistically significant by chi-square test(P<0.05).The positive rate of c-MET in the treatment group was 93.33%,higher than that in the control group(70%),the difference was statistically significant by chi-square test(P<0.05).Comparison of adverse reaction rates:the incidence of adverse reactions in the treatment group is 10%,while that in the control group is 6.67%.Chi-square test showed no significant difference(P>0.05).All the adverse reactions of both groups of patients disappeared after treatment.[Conclusion]Qingchang decoction can significantly improve the clinical symptoms of patients,improve the efficiency of treatment,and is safe and reliable.The mechanism may be increasing the expression of HGF/c-MET,repairing the colonic mucosa,restoring the intestinal epithelial barrier function and reducing the inflammation.