血清ET、重组人内脏脂肪特异性丝氨酸蛋白酶抑制剂检测评估冠心病动脉血管硬化病变程度

Value of Serum ET and Vaspin in Evaluating the Degree of Atherosclerosis in Patients With Coronary Heart Disease

目的研究血清内皮素(endothelin,ET)、重组人内脏脂肪特异性丝氨酸蛋白酶抑制剂检测在评估冠心病患者动脉血管硬化病变程度中应用价值。方法将2017年2月—2018年3月间本院收治132例冠心病患者纳入观察组,另选取同期入院的96例健康体检者为对照组。将观察组分成稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组;另按照冠状动脉病变累及血管支数,将观察组分为单支病变组、双支病变组、三支病变组。分析血清ET、重组人内脏脂肪特异性丝氨酸蛋白酶抑制剂水平与Gensini评分的相关性。结果观察组血清ET水平显著高于对照组(P<0.05),血清重组人内脏脂肪特异性丝氨酸蛋白酶抑制剂水平显著低于对照组(P<0.05)。SAP组血清ET水平显著低于UAP组、AMI组(P<0.05),UAP组血清ET水平显著低于AMI组(P<0.05);SAP组血清重组人内脏脂肪特异性丝氨酸蛋白酶抑制剂水平显著高于UAP组、AMI组(P<0.05),UAP组血清重组人内脏脂肪特异性丝氨酸蛋白酶抑制剂水平显著高于AMI组(P<0.05)。单支病变组血清ET水平显著低于双支病变组、三支病变组(P<0.05),双支病变组血清ET水平显著低于三支病变组(P<0.05);单支病变组血清重组人内脏脂肪特异性丝氨酸蛋白酶抑制剂水平显著高于双支病变组、三支病变组(P<0.05),双支病变组血清重组人内脏脂肪特异性丝氨酸蛋白酶抑制剂水平显著高于三支病变组(P<0.05)。结论血清ET、重组人内脏脂肪特异性丝氨酸蛋白酶抑制剂在冠心病患者动脉血管硬化病变程度评估中具有重要应用价值,临床应引起足够重视。

Objective To study the application value of serum ET and vaspin detection in evaluating the degree of arterial atherosclerotic lesions in patients with coronary heart disease.Methods 132 patients with coronary heart disease admitted to our hospital from February 2017 to March 2018 were included as the observation group,and 96 healthy patients who were admitted to the hospital during the same period were selected as the control group.The observation components were divided into stable angina pectoris group,unstable angina pectoris group,and acute myocardial infarction group.In addition,according to the number of vascular branches involved in coronary artery disease,the observation components were divided into single-vessel disease group,double-vessel disease group,and three-vessel disease group.The correlation between serum ET and vaspin levels and Gensini score was analyzed.Results The serum ET level in the observation group was significantly higher than that in the control group(P<0.05),and the serum vaspin level was significantly lower than that in the control group(P<0.05).Serum ET levels in SAP group were significantly lower than those in UAP and AMI groups(P<0.05).Serum ET levels in UAP group were significantly lower than those in AMI group(P<0.05).Serum vaspin levels in SAP group were significantly higher than those in UAP and AMI groups(P<0.05).The serum vaspin level in the UAP group was significantly higher than that in the AMI group(P<0.05).Serum ET levels in the single-vessel disease group were significantly lower than those in the two-vessel disease group and the three-vessel disease group(P<0.05),and the serum ET levels in the two-vessel disease group were significantly lower than those in the three-vessel disease group(P<0.05);The serum vaspin level of the single-vessel lesion group was significantly higher than that of the double-vessel lesion group and the triple-vessel lesion group(P<0.05),and the serum vaspin level of the double-vessel lesion group was significantly higher than that of the triple-vessel lesion group(P<0.05).Conclusion Serum ET and vaspin have important application value in the assessment of the degree of arterial atherosclerosis in patients with coronary heart disease,and should be paid enough attention in the clinic.