西安地区健康成年女性甲状腺功能分析及正常参考值范围的建立

Analysis of thyroid function and establishment of normal reference ranges for healthy adult women in Xi’an Region

目的探讨西安地区健康成年女性甲状腺功能的特点,制定育龄期和非育龄期女性甲状腺功能的正常参考值范围。方法纳入在我院体检的甲状腺功能正常健康成年女性316例,根据年龄将其分为育龄期组(159例)和非育龄期组(157例)。采用化学免疫发光法测定其总三碘甲腺原氨酸(TT3)、游离三碘甲腺原氨酸(FT3)、总甲状腺激素(TT4)、游离甲状腺激素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)及甲状腺球蛋白抗体(TgAb)的水平,分析两组受试者的甲状腺激素及TSH水平,并制定本地区成年女性甲状腺功能正常参考值范围。结果育龄期组女性的TT3、FT3水平均明显高于非育龄期组(P<0.001)。Pearson相关分析结果显示,健康成年女性的TT3和FT3水平与年龄均呈明显负相关(P<0.001)。本地区育龄期女性甲状腺功能各项指标的正常参考值范围分别为:TT 31.228~2.476 nmol/L,TT 473.791~138.291 nmol/L,FT 33.777~6.296 pmol/L,FT 412.940~20.938 pmol/L,TSH 0.682~5.074μIU/ml;非育龄期女性甲状腺功能各项指标的正常参考值范围分别为:TT 31.143~2.238 nmol/L,TT 464.149~143.017 nmol/L,FT 33.388~5.918 pmol/L,FT 412.197~21.019 pmol/L,TSH 0.631~4.862μIU/ml。结论健康成年女性的FT3和TT3水平随年龄增长而下降,育龄期女性的FT3和TT3水平高于非育龄期女性。有必要对育龄期女性制定甲状腺功能的正常参考值范围。

Objective To study the characteristics of thyroid function of healthy adult women in Xi’an region,and to establish the normal reference ranges of thyroid function for women of childbearing age and non-childbearing age.Methods A total of 316 healthy adult women with normal thyroid function who underwent physical examination in our hospital were collected and divided into childbearing age group(159 cases)and non-childbearing age group(157 cases)according to their age.Total triiodothyronine(TT3),free triiodothyronine(FT3),total thyroid hormone(TT4),free thyroid hormone(FT4),thyrotropin(TSH),antithyroid peroxidase autoantibody(TPOAb)and antithyroglobulin antibody(TgAb)were determined by chemiluminescence.The levels of thyroid hormone and TSH in the two groups were analyzed,and the reference value ranges of thyroid function for adult women were established.Results TT3,FT3 level of women in childbearing age group was significantly higher than that in non-fertility group(P<0.001).Pearson correlation analysis showed that TT3 and FT3 levels of healthy adult women were significantly negatively correlated with age(P<0.001).For women of childbearing age,the normal reference ranges of TT3,TT4,FT3,FT4 and TSH were 1.228~2.476 nmol/L,73.791~138.291 nmol/L,3.777~6.296 pmol/L,12.940~20.938 pmol/L and 0.682~5.074μIU/ml,respectively.For women of non-childbearing age,normal reference ranges of TT3,T 4,FT3,FT4 and TSH were 1.143~2.238 nmol/L,64.149~143.017 nmol/L,3.388~5.918 pmol/L,12.197~21.019 pmol/L and 0.631~4.862μIU/ml,respectively.Conclusion The FT3 and TT3 levels of healthy adult women decrease with age.The FT3 and TT3 levels of women of child-bearing age are higher than those of non-childbearing age.It is necessary to establish the normal reference value ranges of thyroid function for women of child-bearing age.