多奈哌齐联合甲钴胺治疗血管性痴呆的临床效果

Clinical effect of Aricept combined with Mecobalamin in the treatment of vascular dementia

目的 探讨多奈哌齐联合甲钴胺治疗血管性痴呆的效果.方法 选取2018年1~12月镇江市第一人民医院收治的80例血管性痴呆患者,按照随机对照的方法分为联合组(40例)与对照组(40例).联合组患者用多奈哌齐联合甲钴胺进行治疗,对照组患者仅使用多奈哌齐进行治疗.采用简易智能精神状态检查表(MMSE)和蒙特利尔认知评估量表(MoCA)评分比较两组患者治疗前后的认知能力,同时观察两组的不良反应发生情况.结果 两组患者治疗前的MMSE、MoCA评分比较,差异无统计学意义(P>0.05);两组患者治疗后的MMSE、MoCA评分均高于治疗前,差异有统计学意义(P<0.05);联合组患者治疗后的MMSE、MoCA评分高于对照组,差异有统计学意义(P<0.05);与对照组比较,联合组的不良反应无明显增加,差异无统计学意义(P>0.05).结论 多奈哌齐联合甲钴胺能够改善血管性痴呆患者的认知功能和日常生活能力,临床效果确切且安全,优于单独使用多奈哌齐.

Objective To investigate the effect of Aricept combined with Mecobalamin in the treatment of vascular dementia.Methods A total of 80 patients of vascular dementia admitted to the First People′s Hospital of Zhenjiang City from January to December in 2018 were selected and divided into the combinated group(40 cases)and the control group(40 cases)according to the randomized control method.Patients in the combinated group were given Aricept combined with Mecobalamin,while patients in the control group were only given Aricept.The cognitive ability of the two groups before and after treatment was compared,evaluated by mini mental state examination(MMSE)and Montreal Cognitive Assessment(MoCA),at the same time,the adverse reactions of the two groups were observed.Results There were no significant differences in the MMSE,MoCA scores between the two groups before treatment(P>0.05).The MMSE,MoCA scores of the two groups after treatment were higher than those before treatment,the difference were statistically significant(P<0.05).The MMSE,MoCA scores of the combined group were higher than those of the control group,the difference were statistically significant(P<0.05).Compared with the control group,there was no significant increase in adverse reactions in the combined group,without significant difference(P>0.05).Conclusion Aricept combined with Mecobalamin can improve the cognitive function and daily living ability of vascular dementia patients,the clinical effect is accurate and safe,which is better than that of Aricept alone.