婴儿百日咳综合征治疗前后肺功能变化的临床研究

Clinical study on the changes of pulmonary function in infants with pertussis syndrome before and after treatment

目的 探讨婴儿百日咳综合征治疗前后肺功能变化情况.方法 选取2018年6月~2019年1 1月我院收治的63例百日咳综合征患儿为治疗组,同期选择52例在门诊做健康体检的健康婴儿为对照组.比较对照组与治疗组治疗前后肺功能水平,治疗组治疗前后肺功能水平差异,并分析治疗组治疗效果.结果 治疗组治疗前呼吸频率(RR)高于对照组,潮气量(VT)、吸呼比(Ti/Te)、达峰容积比(VPTEF/VE)、达峰时间比(TPTEF/Te)低于对照组,差异均有统计学意义(P<0.05);治疗组治疗后RR、VT、Ti/Te、VPTEF/VE、TPTEF/Te分别为(24.98±5.21)次/min、(8.76±1.16)ml/kg、(0.81±0.13)%、(27.78±8.34)%、(38.84±7.32)%,治疗前分别为(28.56±5.64)次/min、(5.32±1.22)ml/kg、(0.70±0.10)%、(21.49±5.38)%、(21.88±6.69)%,治疗组治疗后RR低于治疗前,VT、Ti/Te、VPTEF/VE、TPTEF/Te高于治疗前,差异均有统计学意义(P<0.05);63例患儿痊愈25例(39.68%),显效21例(33.33%),有效14例(22.22%),无效3例(4.76%),总有效率为95.24%(60/63).结论 婴儿百日咳综合征存在肺功能损害,使用肺功能检测能评估患儿病情,指导治疗,改善病情.

Objective To explore the changes of pulmonary function in infants with pertussis syndrome before and after treatment.Methods A total of 63 cases of pertussis syndrome in our hospital from June 2018 to November 2019 were selected as the treatment group,and 52 cases of healthy infants who had physical examination in the outpatient department were selected as the control group.The lung function level of the control group and the treatment group before and after treatment were compared and the therapeutic effect of the treatment group was analyzed.Results Before treatment,the respiratory rate(RR)of the treatment group was higher than that of the control group,the tidal volume(VT),inspiratory/expiratory ratio(Ti/TE),peak volume ratio(VPTEF/VE),and peak time ratio(TPTEF/TE)were lower than those of the control group,the differences were statistically significant(P<0.05);after treatment,RR,VT,Ti/TE,VPTEF/VE and TPTEF/TE of the treatment group were(24.98±0.21)times/min,(8.76±0.16)ml/kg,(0.81±0.13)%,(27.78±8.34)%,(38.84±7.32)%,respectively,before treatment for(28.56±5.64)time/min,(5.32±1.22)ml/kg,(0.70±0.10)%,(21.49±5.38)%,(21.88±6.69)%,RR in the treatment group was lower than that before treatment,VT,Ti/TE,VPTEF/VE and TPTEF/TE were higher than those before treatment,the differences were statistically significant(P<0.05).All 25 cases were cured(39.68%),18 cases were effective(28.57%),14 cases were effective(22.22%),3 cases were ineffective(4.76%).The effective rate was 95.24%(60/63).Conclusion The lung function of pertussis syndrome in infants is damaged.The detection of lung function can evaluate the condition of children,guide the treatment and improve the condition.