尿促性腺激素、人绒毛膜促性腺激素联合人工周期疗法治疗低促性腺激素闭经所致不孕的临床效果

Clinical effect of the combination of Chorionic Gonadotropin and Human Chorionic Gonadotropin in the treatment of infertility due to hypogonadotropic amenorrhea

目的 探讨尿促性腺激素(HMG)、人绒毛膜促性腺激素(HCG)联合人工周期疗法治疗低促性腺激素闭经所致不孕的临床效果.方法 选取2017年11月~2019年4月我院收治的120例低促性腺激素闭经所致不孕患者为研究对象,采用随机数字表法分为对照组和治疗组,每组各60例.对照组采用常规人工周期治疗,治疗组采用HMG、HCG联合人工周期疗法治疗,比较两组的妊娠成功率、子宫内膜厚度、子宫体积、卵巢体积和优势卵泡及激素水平.结果 治疗组妊娠成功率高于对照组,差异有统计学意义(P<0.05);治疗组子宫内膜厚度、子宫体积、卵巢体积大于对照组,差异均有统计学意义(P<0.05);治疗组优势卵泡多于对照组,差异有统计学意义(P<0.05);治疗组激素水平高于对照组,差异有统计学意义(P<0.05).结论 给予低促性腺激素闭经所致不孕患者HMG、HCG联合人工周期疗治疗效果显著,可有效增加子宫内膜厚度、子宫体积及优势卵泡数,提升激素水平,而提高妊娠成功率,有较高的临床应用价值,值得推广.

Objective To explore the clinical effect of urinary gonadotropin(HMG),human chorionic gonadotropin(HCG)combined with artificial cycle therapy in the treatment of infertility caused by low gonadotropin amenorrhea.Methods A total of 120 cases of infertility caused by low gonadotropin amenorrhea treated in our hospital from November 2017 to April 2019 were selected as the research subjects.They were divided into control group and treatment group by random number table method,60 cases in each group.The control group used conventional artificial cycle.The treatment group was treated with HMG,HCG combined with artificial cycle therapy.The pregnancy success rate,endometrial thickness,uterine volume,ovarian volume,dominant follicles,and hormone levels were compared between the two groups.Results The pregnancy success rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05);the endometrial thickness,uterine volume,and ovarian volume in the treatment group were greater than those in the control group,and the differences were statistically significant(P<0.05).The dominant follicles in the treatment group were more than that in the control group,the difference was statistically significant(P<0.05);the hormone level in the treatment group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion The administration of HMG and HCG combined with artificial cycle therapy for infertility patients caused by low gonadotropin amenorrhea has significant effect,which can effectively increase the thickness of the endometrium,uterine volume and the number of dominant follicles,and improve hormone levels,thereby increasing the success rate of pregnancy,have high clinical application value and are worth promoting.