超敏C反应蛋白与急性心肌梗死患者肾功能损伤的相关性研究

Association between high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction

目的:探讨高敏C反应蛋白(hs-CRP)与急性心肌梗死患者肾功能不全的相关性。方法:对天津医科大学第二医院2019年1月-2019年9月收治的220例急性心肌梗死患者资料进行回顾性分析,根据简化MDRD方程计算估算的肾小球滤过率(eGFR),将患者分为肾功能正常组(141例)、肾功能不全组(79例)。记录患者的一般临床资料及相关生化指标,双变量相关性采用Spearman等级相关。结果:两组饮酒史、高血压、糖尿病、左主干病变、单支血管病变、三支血管病变、住院天数、支架数量、LVEF、LDL、HDL及WBC比较,差异均无统计学意义(均P>0.05)。两组年龄、性别、吸烟史、死亡、双支血管病变、NT-ProBNP、TC、TG、BUN、hs-CRP、Cr比较,差异具有统计学意义(均P<0.05)。肾功能不全组BUN、Cr、hs-CRP、NT-ProBNP均高于肾功能正常组。Spearman相关分析显示,年龄、Cr、BUN、hs-CRP与eGFR呈负相关,是影响eGFR的主要因素。结论:hs-CRP水平在急性心肌梗死合并肾功能不全的患者中升高。

Objective:To investigate whether high-sensitivity C-reactive protein(hs-CRP)is associated with renal dysfunction in patients with acute myocardial infarction.Methods:A retrospective analysis of 220 patients with AMI admitted to the Second Hospital of Tianjin Medical University from January 2019 to September 2019 was included.The patients′eGFR was calculated according to the simplified MDRD equation,and the patients were divided into 141 cases with normal renal function and 79 cases with renal insufficiency.General clinical data and relevant biochemical indicators were recorded.Bivariate correlation was evaluated by using Spearman correlation.Results:There were no significant differences in drinking history,hypertension,diabetes,left main disease,single vessel disease,three vessel disease,length of hospital stay,number of stents,LVEF,LDL,HDL and WBC between the two groups(all P>0.05).The differences in age,smoking,death,and double vessel disease,NT-proBNP,TC,TG,BUN,hs-CRP,Cr were statistically significant between the two groups(all P<0.05).BUN,Cr,hs-CRP,NT-ProBNP in the renal insufficiency group were higher than those in the normal renal function group.Spearman correlation analysis showed that age,Cr,BUN,hs-CRP were negatively correlated with eGFR,which was the main factor affecting eGFR.Conclusion:The level of hs-CRP is elevated in patients with acute myocardial infarction complicated with renal insufficiency.