T2WI、DWI及DCE-MRI联合诊断前列腺癌的效果分析

Efficacy of combined use of T2WI,DWI and DCE-MRI in the diagnosis of prostate cancer

目的:探讨T2加权成像(T2WI)、扩散加权成像(DWI)及动态对比增强磁共振成像(DCE-MRI)联合诊断前列腺癌的价值。方法:选取2017年3月—2019年4月就诊的疑似前列腺癌患者119例,均行常规MRI、DWI和DCE-MRI检查。结果:119例疑似患者中,有69例诊断为前列腺癌,有50例诊断为前列腺增生;T2WI、DWI和DCE-MRI联合诊断前列腺癌的灵敏性为97.10%,明显高于T2WI、DWI单独诊断(均P<0.05);T2WI、DWI、DCE-MRI及联合诊断前列腺癌特异性、准确率比较差异无统计学意义(均P>0.05);前列腺癌Ktrans、KeP、Ve和VP分别为(1.42±0.87)、(1.83±0.80)、(0.84±0.21)和(0.15±0.07),明显高于前列腺增生(均P<0.05),而ADC为(0.92±0.34)×10^-3 mm^2/s,明显低于前列腺增生(P<0.05);Ktrans、KeP、Ve、VP与Gleason评分无相关性(均P>0.05),ADC值与Gleason评分呈负相关(r=-0.508,P<0.05)。结论:T2WI、DWI及DCE-MRI联合用于诊断前列腺癌有较好的效果,其中DWI及DCE-MRI可为诊断提供客观参数。

Objective:To explore the value of combined use of T2-weighted imaging(T2WI),diffusion-weighted imaging(DWI)and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in the diagnosis of prostate cancer.Methods:119 patients with suspected prostate cancer were selected from March 2017 to April 2019,and the routine MRI,DWI and DCE-MRI were performed.Results:Of 119 suspected cases,69 were diagnosed as prostate cancer and 50 were diagnosed as benign prostatic hyperplasia.The sensitivity of combined diagnosis of T2WI,DWI and DCE-MRI for prostate cancer was 97.10%,which were significantly higher than that of single diagnosis of T2WI and DWI(all P<0.05).There were no significant difference in specificity and accuracy of T2WI,DWI,DCE-MRI and combined diagnosis of prostate cancer(all P>0.05).Ktrans,KeP,Ve and VP of prostate cancer were(1.42±0.87),(1.83±0.80),(0.84±0.21)and(0.15±0.07)respectively,which were significantly higher than those of benign prostatic hyperplasia(all P<0.05),while ADC was(0.92±0.34)×10^-3 mm^2/s,which was significantly lower than that of benign prostatic hyperplasia(P<0.05).Ktrans,KeP,Ve and VP were not correlated with Gleason score(all P>0.05),but ADC was negatively correlated with Gleason score(r=-0.508,P<0.05).Conclusion:The combination of T2WI,DWI and DCE-MRI has a good effect in the diagnosis of prostate cancer,and DWI and DCE-MRI can provide objective parameters for the diagnosis.