胰岛素抵抗相关的皮肤病

Skin Diseases Related to Insulin Resistance

皮肤病种类繁多,有些皮肤病仅累及皮肤,但某些皮肤病不仅累及皮肤,还与机体系统性疾病有关,可能是疾病的外在表现,常作为机体潜在疾病的诊断线索。近年来,代谢相关性皮肤病逐渐引起人们的重视,与代谢性疾病密切相关的胰岛素抵抗(IR)是2型糖尿病的主要发病机制,许多皮肤病(如黑棘皮病、痤疮、银屑病、雄激素性脱发、化脓性汗腺炎和多毛症)的发病可能也与IR有关。因此,对相关皮肤病发生和发展中IR相关机制的研究,有助于相关皮肤病的预防及治疗。

There are many kinds of skin diseases.Some skin diseases only involve the skin,while some skin diseases not only involve the skin,but also are related to systemic diseases of the body,which may be the external manifestations of other diseases,and are often the diagnostic clues of potential diseases of the body.In recent years,more and more attention has been paid to metabolic skin diseases.Insulin resistance(IR),which is closely related to metabolic diseases,is the main pathogenesis of type 2 diabetes.Many skin diseases,such as acanthosis nigricans,acne,psoriasis,androgenic alopecia,hidradenitis suppurativa and hirsutism,have also been found to be possibly related to IR.Therefore,the study of IR related mechanisms in the occurrence and development of related skin diseases is helpful for the prevention and treatment.