结合全草花叶类中药煎煮相对密度监测模型探讨中药汤剂的质量控制

Discussing the Quality Control of Traditional Chinese Medicine Decoction by Combining the Relative Density Monitoring Model of Herbal Decoction of Whole Grass Flower and Leaf

目的建立全草花叶类中药煎煮相对密度预测区间的数学模型,探讨中药汤剂的质量控制。方法通过测定使用频次高、具有一定代表性的29种全草花叶类中药的煎煮吸水率、得液量、相对密度、出膏率等关键参数,以相对密度与出膏率的线性回归方程为基础,建立全草花叶类中药复方汤剂相对密度预测区间数学模型;并以单味及7种全草花叶类中药复方煎煮实验测定的相对密度验证该数学模型。结果29种全草花叶类中药煎煮的相对密度(Y)对出膏率(X,%)的线性回归方程为:Y=0.0003 X+1.0002,r=0.9593,线性范围为5.2%~53.3%,相对密度对出膏率的线性关系显著;全草花叶类中药复方汤剂相对密度95%预测区间的数学模型为:Y预测=(0.0003 X复方+1.0002)±0.002152×√30/29+(X复方-21.2)^2/3793.7,验证实验结果在数学模型预测区间范围内。结论该研究建立的数学模型可用于预测全草花叶类中药复方汤剂的相对密度,可为中药汤剂的质量控制提供依据。

Objective To establish a mathematical model to predict the relative density interval of Traditional Chinese medicine decoction of whole grass flower and leaf and to explore the quality control of traditional Chinese medicine decoction Methods A total of 29 kinds of representative Chinese medicine of whole grass flower and leaf,which was high frequently used in clinic,was selected.By measuring the key parameters such as the water absorption,liquid output,extraction rate and relative density the mathematical model of the relative density interval of decoction is established based on the linear regression equation of relative density and extraction rate.The model was verified by the relative density of a single formulation and a compound formulation consisted by 7 kinds of whole grass flower and leaf.Results The linear regression equation of relative density(Y)to extraction rate(X,%):Y=0.0003 X+1.0002,r=0.9593,linear range was 5.2%-53.3%.The linear relationship of relative density to extraction rate is significant.The 95%prediction interval of relative density of compound decoction is Y prediction=(0.0003 X compound+1.0002)±0.002152×√30/29+(X compound-21.2)^2/3793.7.The results of the verification experiment were within the prediction range of the mathematical model.Conclusion The mathematical model established in this study can be used to predict the relative density of compound traditional Chinese medicine decoction consisted by whole grass flower and leaf.The research can provide references for quality control of traditional Chinese medicine decoction.