期刊文献+

晚期非小细胞肺癌放射治疗联合靶向治疗效果分析

下载PDF
导出
摘要 目的:探讨晚期非小细胞肺癌(NSCLC)放射治疗联合靶向治疗的效果。方法:将南部战区总医院2018年1月至2019年6月收治的90例诊断为晚期NSCLC患者,按随机抽样法分成对照组和观察组(各45例)。对照组接受放射治疗,观察组患者在放射治疗的基础上,增加表皮生长因子受体–酪氨酸激酶抑制剂(EGFR–TKI)进行靶向治疗。分析两组患者的临床疗效、并发症等情况的差异。结果:观察组总有效率为88.89%,大于对照组75.56%,差异具有统计学意义(P<0.05);观察组患者并发症发生率低于对照组,差异具有统计学意义(P<0.05)。结论:放射治疗联合靶向治疗能改善晚期NSCLC患者的治疗总有效率和降低并发症的发生率。
作者 黄彦泽 周娟
机构地区 南部战区总医院
出处 《深圳中西医结合杂志》 2020年第9期21-22,共2页 Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
  • 相关文献

参考文献8

二级参考文献61

  • 1Riely GJ, Politi KA, Miller VA, et al. Update on epidermal groxah factor receptor ntations in non-small cell lung cancer [ J ], Clin Cancer Res, 2006, 12(24):7232-7241.
  • 2Onitsuka T, Uramoto H, Nose N, et al. Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status[J]. Lung Cancer, 2010, 68(2) :198-203.
  • 3Su KY, Chen HY, Li KC, et al. Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non- small-cell lung cancer [ J ]. J Clin Oncol, 2012, 30 ( 4 ) : 433 -440.
  • 4Shi Y, Au JS, Thongprasert S, et al. A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER) [J]. J Thorac Oncol, 2014, 9(2):154-162.
  • 5Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer[ J]. Nature, 2007, 448(7153) :561-566.
  • 6Zhang X, Zhang S, Yang X, et al. Fusion of EMLA and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression [J]. Mol Cancer, 2010, 9:188.
  • 7Zhang NN, Liu YT, Ma L, et al. The molecular detection and clinical significance of ALK rearrangement in selected advanced non-small cell lung cancer: ALK expression provides insights into ALK targeted therapy[ J]. PLoS One, 2014, 9 ( 1 ) : e84501.
  • 8Sequist LV, Martins RG, Spigel D, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations[J]. J Clin Oncol, 2008, 26(15) :2442-2449.
  • 9Mitsudnmi T, Morita S, Yatabe Y, et al. Gefitlnib versus eisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WYrOG5405): an open label, randnmised phase 5 trial [ J ]. Lancet Oncol, 2010, 11 (2) : 121-128.
  • 10Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation- positive non-small-cell lung cancer (OPTIMAL, CTONG-0802 ) : a multicentre, open-label, randomised, phase 3 study[J]. Lancet Oneol, 2011, 12 ( 8 ) : 735-742.

共引文献343

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部