纵行黑甲243例临床及病理分析

Clinical and Histopathotogic Studies of 243 Cases of Longitudinal Melanonychia

目的分析纵行黑甲的临床和病理特点。方法回顾性分析243例纵行黑甲切除/活检术患者的临床表现及组织病理学特点。结果243例患者中,甲黑素细胞活化113例,甲母痣(良性黑素细胞增生)62例,甲黑素瘤42例,其他26例。甲黑素瘤临床表现多样,可以为褐色、黑色或不均一条带,第一指(趾)甲为最常见的甲黑素瘤发病部位,而多个甲受累为甲黑素瘤的保护因素。结论对纵行黑甲应仔细评估,临床评估有疑问或皮损变化的情况下,应及时进行指甲活检以除外甲黑素瘤。

Objective To analyze the clinical and pathological characteristics of longitudinal melanonychia.Methods The clinical and histopathological features of 243 patients who underwent resection/biopsy of longitudinal melanonychia were analyzed retrospectively.Results Among 243 cases,113 cases were melanocytic activation,62 cases were nevus of the nail matrix(benign melanocytosis),42 cases were nail melanoma,26 cases were others.The clinical manifestations of nail melanoma were various,which can be brown,black or uneven bands.The first nail or toenail was the most common site of nail melanoma,and multiple nail involvement was the protective factor of nail melanoma.Conclusion The longitudinal melanonychia should be evaluated carefully.In case of doubt or change of skin lesions in clinical evaluation,nail biopsy should be carried out in time to differential the melanoma.