Nod样受体蛋白3炎症小体在寄生虫病中的研究进展

Advances in research on Nod-like receptor protein 3 inflammasome in parasitic diseases

炎症小体作为固有免疫系统的感受器,活化后可以参与抵抗病原生物体的应激反应。本文总结归纳了Nod样受体蛋白3(NLRP3)炎症小体的基本结构、功能及其在疟疾、溶组织内阿米巴病、克氏锥虫病、利什曼原虫病、血吸虫病、阴道毛滴虫病中的相关研究,旨在分析NLRP3炎症小体在寄生虫病中的作用及机制,为干预与治疗手段优化提供思路。

Inflammatory corpuscles are receptors of the innate immune system and participate in the stress responses against pathogenic organisms after activated.This review summarizes the basic structure and functions of Nod-like receptor protein 3(NLRP3)inflammasome as well as the related researches on malaria,amoebic disease,trypanosomiasis,leishmaniasis,schistosomiasis,and vaginal trichomoniasis,aiming to analyze the role and mechanism of NLRP3 inflammasome in parasitic diseases and provide ideas for better interventions and treatment.