猛超载参与阿尔茨海默病病理改变的研究进展

Advance of manganese overload involved in the pathogenesis of Alzheimer’s disease

阿尔茨海默病(Alzheimer disease,AD)是一种以认知功能障碍为主要临床特征的神经退行性疾病,AD患者大脑中有金属离子的异常分布,其中锰离子的病理作用近年来倍受关注。锰离子可通过血脑屏障,锰离子暴露者出现认知功能受损,但是,目前其机制尚不清楚。本综述旨在分析金属锰离子超载对Aβ蛋白的产生及聚集、Tau蛋白异常磷酸化、线粒体代谢和p53的影响,阐述锰与AD发病的相关性。

Alzheimer disease(AD)is a neurodegenerative disease characterized by cognitive dysfunction,the abnormal distribution of metal ions exists in the post-mortem of AD brains.Manganese ions can pass through the bloodbrain barrier,and cognitive function is impaired in persons under chronic exposure to manganese ions.However,the mechanism underlined is still unclear,this review is to discuss the effects of metal manganese ions overload on the production and aggregation of Aβ,abnormal phosphorylation of Tau protein,mitochondrial metabolism and p53,and to state the relationship between manganese and AD.