酸离子敏感通道1a在炎症性疾病中的研究进展

Research progress of ASIC1a in inflammatory diseases

酸离子敏感通道1a(acid-sensing ion channel 1a,ASIC1a)属于氨氯敏感配体门控离子通道,在中枢和外周神经系统中广泛分布及表达。在生理环境下,细胞通过H^+的多种转运方式维持细胞外和细胞内的pH值并相对稳定在7.0~7.5左右。在一些病理条件如过敏性哮喘、肾炎、关节炎、肠炎、急性肺损伤等炎症性疾病的发生过程中,由于组织的无氧糖酵解产生乳酸和ATP水解的H^+积聚,导致组织酸化及体液pH值急剧下降至4.0~6.0左右,而进一步激活的ASIC1a可引起炎症性疾病病情急剧恶化。近年来,靶向ASIC1a可能是一种潜在的治疗策略,本文就ASIC1a在炎症性疾病中的作用做简要综述,探讨ASIC1a在炎症性疾病中的研究进展。

Acid-sensing ion channel 1 a(ASIC1 a) is an ammonia-chlorine-sensitive ligand-gated ion channel,and is widely distributed and expressed in the central and peripheral nervous systems. In a physiological environment, cells maintain a stable pH value around 7.0-7.5 through various transport modes of H+. During the occurrence of some pathological conditions such as allergic asthma, nephritis, arthritis, enteritis, acute lung injury, and other inflammatory diseases, the anaerobic glycolysis of tissue produces H+accumulation of lactic acid and ATP hydrolysis, resulting in tissue acidification and body fluids. The pH value drops sharply to around 4.0-6.0, which further activates ASIC1 a, causing a sharp deterioration of the inflammatory disease. In recent years, targeting ASIC1 a may be a potential treatment strategy. This review briefly summarizes the role of ASIC1 a in inflammatory diseases and discusses the research progress of ASIC1 a in inflammatory diseases.