超声引导下聚桂醇硬化术治疗良性甲状腺囊肿的疗效及安全性分析

Efficacy and safety of ultrasound-guided lauromacrogol sclerotherapy for benign thyroid cyst

目的探讨超声引导下聚桂醇硬化术治疗良性甲状腺囊肿(BTC)的疗效及安全性。方法选取2017年6月至2019年6月本月BTC患者180例,按随机数字表分为聚硬组(n=80)和乙硬组(n=80),聚硬组给予超声引导下聚桂醇硬化术,乙硬组给予超声引导下无水乙醇硬化术,比较两组囊腔体积、治疗疗效、并发症、不良反应。结果聚硬组和乙硬组术后1、3、6个月囊腔体积明显低于术前,差异有统计学意义(P<0.05),聚硬组和乙硬组术后1、3、6个月囊腔体积比较差异无统计学意义(P>0.05);聚硬组和乙硬组治疗有效率、并发症率比较差异无统计学意义(P>0.05);聚硬组不良反应率明显低于乙硬组,差异有统计学意义(P<0.05)。结论与无水乙醇比较,超声引导下聚桂醇硬化术也可有效缩小BTC患者囊腔体积,具有良好的疗效及安全性,可减轻患者不良反应,值得临床推广。

Objective To discuss the efficacy and safety of ultrasound-guided lauromacrogol sclerotherapy for benign thyroid cyst( BTC).Methods 180 patients with BTC in our hospital were selected from June 2017 to June 2019,they were divided into the Juying group( n = 80) and Yiying group( n = 80).The Juying group was treated with ultrasound-guided lauromacrogol sclerotherapy,the Yiying group was treated with ultrasound-guided anhydrous ethanol sclerotherapy. The sclerotherapy,therapeutic effect,complications and adverse reactions were compared between the two groups. Results The cysts volume in the Juying group and the Yiying group at 1,3,6 months after operation was significantly lower than that before operation,the difference was statistically significant( P<0.05),there was no significant difference between the Juying group and Yiying group in the cysts volume at 1,3 and 6 months after operation( P>0.05).There was no significant difference in the effective rate and complication rate between the Juying group and Yiying group( P>0.05). The adverse reaction rate in the Juying group was significantly lower than that in the Yiying group,the difference was statistically significant( P < 0.05). Conclusions Compare with anhydrous ethanol,ultrasound-guided lauromacrogol sclerotherapy can also effectively reduce the cysts volume of patients with BTC,which has the good efficacy and safety,and it can reduce the adverse reactions of patients,it’s worth for further clinical promotion.