炎症细胞因子在卵巢上皮癌化疗耐药中的作用

The role of inflammatory cytokines in chemoresistance of epithelial ovarian cancer

卵巢癌是女性常见的致命性恶性肿瘤,最常见的病理类型是起源于卵巢或输卵管上皮的卵巢上皮癌(EOC),约占85%~90%。EOC患者的标准治疗方法是肿瘤细胞减灭术,术后进行铂类/紫杉醇化疗,细胞的化疗耐药已成为EOC患者复发并走向死亡的重要原因。目前已有许多学者认为卵巢癌的肿瘤环境富含广谱的肿瘤促炎细胞因子和趋化因子。炎症能使上皮细胞分裂分化增加,正常的上皮组织长期暴露于炎性环境会逐渐向恶性转化,炎性肿瘤微环境促进转变的恶性肿瘤细胞侵袭、转移,最终发生耐药。

Ovarian cancer is a common fatal malignant tumor in women.The most common pathological type is epithelial ovarian cancer(EOC)originating from the ovary or fallopian tube epithelium,accounting for 85%-90%.The standard treatment for EOC is tumor cytoreductive surgery.Postoperative platinum/paclitaxel chemotherapy,cell chemoresistance has become an important cause of recurrence and death in EOC patients.At present,many scholars believe that the tumor environment of ovarian cancer is rich in a broad spectrum of tumor pro-inflammatory cytokines and chemokines.Inflammation can increase the division and differentiation of epithelial cells.The long-term exposure of normal epithelial tissues to the inflammatory environment will gradually turn to malignant transformation.The inflammatory tumor microenvironment promotes the invasion and metastasis of transformed malignant tumor cells,and eventually develops drug resistance.