阿比多尔致新型冠状病毒肺炎患者皮疹

Rashes caused by arbidol in a patient with novel coronavirus pneumonia

1例50岁男性焦虑性抑郁症、高脂血症患者因新型冠状病毒感染,在既往服用喹硫平、氯硝西泮和阿托伐他汀钙的基础上给予口服阿莫西林克拉维酸钾0.5 g、1次/d,洛匹那韦/利托那韦2片、2次/d。3 d后,因患者发生可疑药物相互作用,将洛匹那韦/利托那韦改为口服阿比多尔200 mg、3次/d。服用阿比多尔3 d后,患者全身出现红色丘疹。考虑可能与阿莫西林克拉维酸钾有关,停用该药并给予氯雷他定,皮疹继续加重。考虑为阿比多尔引起的药疹,停用阿比多尔,次日患者皮疹大面积消退。加用维生素C注射液、葡萄糖酸钙注射液和利巴韦林。5 d后,患者皮疹完全消退;17 d后,患者肺炎痊愈。

A 50-year-old male patient with agitated depression and hyperlipemia received oral amoxicillin and clavulanate potassium 0.5 g once daily and 2 lopinavir and ritonavir tablets twice daily for novel coronavirus infection,based on previous drugs including quetiapine,clonazepam,and atorvastatin calcium.After 3 days,lopinavir and ritonavir was changed to oral arbidol 200-mg,thrice daily due to suspicious drug interaction.After taking arbidol for 3 days,the patient developed red papules on the whole body.Considering that it might be related to amoxicillin and clavulanate potassium,the drug was stopped and loratadine was given.But the rashes were aggravated.Considering that the drug eruption was caused by arbidol,arbidol was discontinued and the rashes subsided in a large area the next day.Then vitamin C injection,calcium gluconate injection,and ribavirin were added.After 5 days,the rashes subsided completely.After 17 days,the patient recovered from pneumonia.