内皮细胞焦亡及其相关疾病的研究进展

Research advances in pyroptosis of endothelial cells and related diseases

内皮细胞结构和功能的改变是许多疾病发生的病理基础。细胞焦亡是最近发现的一种细胞程序性死亡方式,表现为细胞不断胀大直至破裂,细胞内容物释放,激发炎性反应。内皮细胞焦亡在动脉粥样硬化、心肌缺血再灌注损伤、急性肺损伤、创伤性脑损伤、糖尿病等多种疾病的发生、发展中起重要的作用。本文就近年来有关内皮细胞焦亡及其相关疾病的研究现状进行综述。

Structural and functional changes of endothelial cells are the basic pathology of many diseases.Pyroptosis is a kind of newly discovered programmed cell death which causes the formation of large pores in the membrane that drive swelling and membrane rupture.Membrane rupture disperses cytosolic contents which further elicit a systemic inflammatory response.Pyroptosis of endothelial cells make a difference in the occurrence and developement of many diseases,including Atherosclerosis,myocardial ischemia-reperfusion injury,acute lung injury,traumatic brain injury and diabetes.In this article,the progress over the years of the research on the involvement of vascular endothelial cells in the pyroptosis is reviewed.