柴胡疏肝汤加减治疗抑郁气郁证的临床疗效

Clinical effect of Chaihu shugan decoction in treating depression patients with Qi depression syndrome

目的:探究柴胡疏肝汤加减治疗抑郁气郁证的临床疗效及对血清5-HT、IL-6水平的影响。方法:选取我院收治的抑郁症患者86例,随机分为对照组(n=43)和观察组(n=43)。对照组给予盐酸多塞平片治疗,观察组在此基础上给予柴胡疏肝汤加减治疗,两组均连续治疗8周。统计两组治疗8周后临床疗效,比较两组治疗前后血清因子水平和抑郁改善情况。结果:观察组临床总有效率81.40%(35/43)明显高于对照组的60.47%(26/43)(P<0.05),两组血清5-HT水平较治疗前升高,观察组高于对照组(P<0.05),两组血清IL-6、TNF-α水平较治疗前降低,观察组低于对照组(P<0.05),治疗8周期间,两组HAMD评分、SDS评分随治疗时间的延长呈下降趋势,治疗4周、8周后观察组低于对照组(P<0.05)。结论:柴胡疏肝汤加减治疗抑郁气郁证通过降低炎症因子水平,增加5-HT含量,改善抑郁症状,效果显著。

Objective:To explore the clinical effect of Chaihu shugan decoction in the treatment of depression patients with Qi depression syndrome and its effect on serum 5-HT and IL-6 levels. Methods:A total of 86 patients with depression treated in our hospital were randomly divided into the control group(n=43) and the observation group(n=43). The control group was given doxepin hydrochloride tablets,and the observation group was given Chaihu shugan decoction plus or minus treatment. Both groups were treated continuously for 8 weeks. Statistical analysis of the clinical efficacy of the 2 groups after 8 weeks of treatment;The serum factor levels and depression improvement before and after treatment were compared between the two groups of patients.Results:The total clinical effective rate of 81.40%(35/43)in the observation group was significantly higher than that in the control group by 60.47%(26/43)(P<0.05). The serum 5-HT in the two groups was higher than before the treatment,and the observation group was higher than the control group(P<0.05). The serum IL-6 and TNF-α in the two groups were lower than before the treatment,and the observation group was lower than the control group(P<0.05). During 8 weeks of treatment,the HAMD score and SDS score of the two groups showed a downward trend with the extension of treatment time,and the observation group was lower than the control group after 4 and 8 weeks of treatment(P<0.05). Conclusion:Chaihu shugan decoction for the treatment of depression patients with Qi-stagnation syndrome by reducing the level of inflammatory factors,increasing the content of 5-HT,and then improving the symptoms of depression,the effect is significant.