抑郁症患者自身因素对其服药依从性的影响

Influence of self-factors on compliance of patients with depression

目的探讨抑郁症患者服药依从性的影响因素.方法从北京安定医院精神疾病临床数据与生物样本库的受试者数据库中选取符合分析要求的轻中度抑郁症患者(n=102),按照服药依从性分为两组,依从性好组(n=40)和依从性差组(n=62).通过分析比较两组在年龄、性别、受教育年限、居住地、婚姻状况、居住情况、家庭关系、家庭经济状况、发作次数、固定医生和疾病严重程度等方面的差异,探讨上述因素对于患者服药依从性的影响.结果经单因素分析依从性好组和依从性差组在受教育年限、居住情况、家庭关系、家庭经济状况、发作次数、固定医生方面具有差异,差异有统计学意义(χ2/Z=8.516、6.030、6.706、5.192、5.170、4.809,均P<0.05),且上述条目经Logistic回归分析显示均与患者服药依从性相关(均P<0.05).结论家庭关系不和睦、独居、家庭经济状况差、发作次数多、医生不固定、教育水平低的轻中度抑郁症患者服药依从性更低.

Objective To discuss the influencing factors of medication adherence in patients with depression.Methods Patients with mild to moderate depression(n=102)were selected from the clinical data of mental disorders and the biological samples bank in Beijing Anding Hospital.According to the drug compliance,they were divided into two groups:the group with good compliance(n=40)and the group with poor compliance(n=62).The influencing factors of drug compliance were explored by analyzing and comparing the differences between the two groups in age,gender,years of education,place of residence,marital status,living situation,family relationship,family economic status,frequency of attack,certain doctors and disease severity.Results According to the single factor analysis,there were significant differences between the group with good compliance and the group with poor compliance in terms of education years,living conditions,family relations,family economic status,attack frequency and fixed doctors(test value=8.516,6.030,6.706,5.192,5.170,4.809,P<0.05).Logistic regression analysis showed that the above items in both groups were related to the compliance of patients with medication(P<0.05).Conclusions The patients with disharmonious family relationship,living alone,poor family economic status,frequent attacks,unstable doctors and low education level have lower drug compliance.