艾普拉唑治疗十二指肠溃疡的Meta分析及药物经济学评价

Meta-analysis and Pharmacoeconomic Evaluation of Ilaprazole in the Treatment of Duodenal Ulcer

目的综合评价艾普拉唑治疗十二指肠溃疡(DU)的有效性及安全性,从医疗机构角度比较患者接受艾普拉唑治疗方案的经济学。方法通过检索公开发表的有关艾普拉唑治疗DU的文献,采用Cochrane系统评价方法对文献进行质量评价,应用RevMan5.3软件对文献报道的有效性及安全性数据进行Meta分析。根据Meta分析的结果,选择成本-效果分析法或最小成本分析法比较艾普拉唑治疗方案的经济学。结果本研究共纳入8篇文献,共计1144例患者。Meta分析结果显示,艾普拉唑给药方案比奥美拉唑给药方案溃疡愈合率更高(91.77%/87.70%)、Hp清除率更高(93.14%/86.14%)、不良反应发生率更低(9.13%/12.7%)。成本-效果比(C/E)分析结果显示,艾普拉唑治疗方案更具经济学。结论艾普拉唑价格高于奥美拉唑,综合考量临床疗效及治疗成本,选择艾普拉唑治疗方案治疗十二指肠溃疡患者获益更大。

Objective To generally evaluate the effectiveness and safety of the Ilaprazole in treatment of duodenal ulcer(DU),and to compare the economical efficiency of the patients having therapy of Ilaprazole from the perspective of medical institutions.Methods The published literature on the treatment of DU by Ilaprazole were searched,and the quality of literatures were evaluated by the Cochrane systematic evaluation method.Meta-analysis of the effectiveness and safety data of the literature and reports were carried out by using the RevMan 5.3 software.According to the results of Meta-analysis,the economical efficiency of Ilaprazole therapy was compared with the Cost-effectiveness analysis or Minimum cost method.Results A totally 8 literature were adopted in this research,with 1144 patients.Meta-analysis results showed that,compared with the Omeprazole therapy,the Ilaprazole therapy had higher ulcer healing rate(91.77%/87.70%),higher HP clearance rate(93.14%/86.14%)and lower rate(9.13%/12.7%)in the incidence of adverse reactions.The Cost-effectiveness(C/E)analysis results showed that Ilaprazole therapy was more economical.Conclusion Although the price of eprazole is higher than that of omeprazole,comprehensively considering the clinical effects and treatment cost,the patients with duodenal ulcer will benefit more from the treatment of eprazole.