由代谢免疫及氧化应激角度探寻新型冠状病毒肺炎治疗方向及有效药物

Exploring COVID-19 Treatment and Effective Medicine from Immunometabolism and Oxidative Stress

免疫反应可以引起细胞代谢重新编程,而变化的代谢方式为免疫反应提供了必须的条件基础,并促进免疫反应进行。免疫反应过程及代谢改变又诱发了大量活性氧簇(ROS)的产生,引起氧化应激,对细胞及组织带来损伤,并进一步诱导炎性因子,促进免疫反应。病毒入侵机体后,过激的免疫反应及引起氧化应激是病毒感染后主要伤害来源之一,通过分析免疫反应诱发的代谢方式改变,及氧化应激通路,找寻调控靶点。通过网络药理学方法筛选具有潜在治疗效果的中药,为治疗新型冠状病毒肺炎提供新的治疗途径与方法。

Immune response can cause reprogramming of cellular metabolism.The changing of metabolic mode provides necessary conditions for immune response,and promotes immune response.Immune response and the changing of metabolic way can induce a large number of ROS,cause oxidative stress,cell and tissue damage,and further induces inflammatory factors and promotes the immune response.After the virus invades the body,excessive immune response and oxidative stress are main sources of damage after viral infection.We analyzed changes in metabolic way induced by immune response and oxidative stress to find out regulatory targets andscreen effective Chinese medicines through network pharmacology in order to provide a new therapeutic approach for COVID-19.