家庭聚集性新型冠状病毒肺炎患者临床特点分析

Clinical features of family clustering coronavirus disease 2019

目的初步探讨新型冠状病毒肺炎(COVID-19)家庭聚集性发病的流行病学及临床特点。方法分析湖北省十堰市新冠肺炎第二定点救治医院2020年2月3—6日收治确诊的6组家庭聚集性COVID-19患者流行病学、临床症状、实验室检查、胸部CT检查结果。结果6组家庭共26人,男15人,女11人,其中18人发病,男8例(8/18),女10例(10/18),女性发病率高于男性;患者平均年龄(47.28±12.05)岁,未发病8人平均年龄(13.81±10.64)岁,中老年人更易发病;发病症状多以发热(12/18)、咳嗽(6/18)为首发症状;病初患者WBC、中性粒细胞计数(N)、淋巴细胞计数(L)多正常或偏低[(4.55±1.8)×10^9/L、(2.74±1.24)×10^9/L、(1.39±0.53)×10^9/L],CRP多升高(30.96±3.97)μg/ml;患者胸部CT早期呈现多发小斑片状影及间质改变,以肺外带明显,进而发展为双肺多发磨玻璃影、浸润影,严重者可出现肺实变。结论COVID-19家庭聚集性发病现象明显,不同性别、年龄发病率有一定差异,正确掌握家庭聚集性COVID-19的临床特点,有利于早期阻断家庭聚集传播、早发现、早治疗。

Objective To investigate the features of epidemiology,clinical symptoms,leukocytes,CRP,and chest CT of novel coronavirus pneumonia(COVID-19)patients of clustered onset in families.Methods To analyze the epidemiology,clinical symptoms,WBC,CRP,and chest CT examination results of 6 groups of family-aggregated COVID-19 patients diagnosed and treated on February 3-6,2020,Novel Coronary Pneumonia Second Designated Treatment Hospital,Shiyan City,Hubei Province.Results Among the 26 families(15 males and 11 females)in 6 groups,18 were sick,8 males(8/18)and 10 females(10/18).The incidence of females was higher than that of males;the average age of patients was(47.28±12.05)years old,the average age of 8 people without disease(13.81±10.64)years old,middle-aged and elderly people are more prone to onset;most of the symptoms are fever(11/18),cough(6/18)as the first symptom;WBC,neutrophil count(N),lymphocyte count(L)is usually normal or low[(4.55±1.8)×10^9/L,(2.74±1.24)×10^9/L,(1.39±0.53)×10^9/L].CRP increased(30.96±3.97)μg/ml;patients with early chest CT showed multiple small patchy shadows and interstitial changes,with obvious extrapulmonary bands,and then developed multiple ground glass and infiltration shadows of the lungs.Lung consolidation may occur.Conclusion The clustering of COVID-19 in families is obvious.There is a certain difference in the incidence of different sexes and ages.Correctly grasping the clinical characteristics of family clustering COVID-19 is helpful to early block the spread of family aggregation,early detection and early treatment.