肺动脉高压基因遗传突变研究进展

Progress in genetic mutation of pulmonary hypertension gene

肺动脉高压(PAH)是一种罕见的血管疾病,肺动脉高压的病理生理机制复杂,其发生发展受环境因素和遗传因素影响。近些年,在肺动脉高压遗传因素的研究中,越来越多的异常基因被发现;随着对基因机制的研究不断进展,相关的靶向治疗也为肺动脉高压诊治提供了新的思路与新选择。

Pulmonary hypertension(PAH)is a rare vascular disease.The pathophysiology of PAH is complex.Its occurrence and development are affected by environmental factors and genetic factors.In recent years,more and more abnormal genes have been found in the study of genetic factors of pulmonary hypertension.With the development of gene mechanism,targeted therapy also provides new ideas and new options for the diagnosis and treatment of pulmonary hypertension.