靶向TSPO的神经炎症成像分子探针

Molecular Probes Targeting TSPO for Neuroinflammatory Imaging

神经炎症贯穿神经退行性疾病的整个发病过程。在正常的生理状态下,神经炎症有助于神经系统损伤的修复,但当炎症反应过度时则会造成细胞的损伤,加速神经退行性疾病的恶化。当神经炎症发生时,小胶质细胞会异常活化。这使它们成为反映小胶质细胞病理生理学改变的一种敏感而特异的定量指标。本文主要通过核素和可见光成像技术对神经炎症靶点进行检测,介绍了近年来TSPO靶点分子探针的研究进展,包括核素成像和荧光成像。最后展望了神经炎症分子探针的研究方向,对于开发更清晰、方便、经济的神经炎症分子探针有一定的借鉴意义。

Neuroinflammation runs through the whole course of neurodegenerative diseases.In normal physiological state,nerve inflammation contributes to the repair of nervous system damage,while excessive inflammation can cause cellular damage,accelerating the deterioration of neurodegenerative diseases.When nerve inflammation occurs,microglia cells are activated,which makes them a sensitive and specific quantitative indicator to reflect the pathophysiological changes of microglia cells.Nuclide and visible light imaging technologies were used to detect neuroinflammatory targets,and the research progress of molecular probes targeting TSPO targets in recent years was introduced,including nuclide imaging and fluorescence imaging.Finally,the application prospect and market value of the neuroinflammatory molecular probes are summarized and forecasted,which is of certain reference significance for the development of novel neuroinflammatory molecular probes.