循证医学视角下运动对绝经后女性血脂的影响

Exercise Training on Lipid Profile in Postmenopausal Womenfrom the Perspective of Evidence-based Medicine

为了从循证医学视角,探讨规律运动对绝经后女性血脂的影响效果,从而为绝经后女性的科学运动做出更为准确可靠的指导。运用Stata 12.1软件对所纳入文献的结局指标进行分析。结果表明:在纳入的14篇文献中,涵盖研究对象540例(实验组298例,对照组301例)。研究间具有同质性(I 2=47.3%,P=0.025),合并效应量SMD=-0.34,95%CI[-0.58,-0.10],合并效应量置信区间及垂直虚线(效应线)相交落在无效线左侧,差异具有非常显著性(P=0.00<0.01)。可以认为有运动干预的绝经后女性与无运动干预的绝经后女性相比,其血脂TC值的SMD有统计学差异。得出结论:规律运动尤其是有氧运动对绝经后女性血脂代谢的影响是通过降低血浆中TG、TC、LDL-C水平而起到降血脂的作用,但对HDL-C作用效果不大。

To explore the effect of regular exercise on postmenopausal women s blood lipids,to provide reference for the formulation of exercise prescription and to improve the life quality of postmenopausal women.Methods:Stata 12.1 software was used to analyze the outcome index.Results:540 subjects(experimental group 298 cases,control group 301 cases)were included in 14 articles.There was homogeneity in the study(I 2=47.3%,P=0.025),and the combined effect was SMD=-0.34,95%CI[-0.58,-0.10].The confidence interval of combined effect and vertical dashed line(effect line)intersected to the left of invalid line,and the difference was very significant(P=0.00<0.01).It can be concluded that there is a statistical difference in SMD between postmenopausal women with exercise intervention and postmenopausal women without exercise intervention.Conclusion:the effect of regular exercise on lipid metabolism of postmenopausal women,especially aerobic exercise,is by reducing the level of TG,TC,LDL-C in plasma,but it has little effect on HDL-C.