摘要
伪狂犬病病毒(PRV)是猪伪狂犬病的病原体,在世界范围内造成了毁灭性的疾病和经济损失。由于该病毒的嗜神经性,因此引起病毒学家和神经生物学家的高度兴趣。当前,PRV已经成为研究疱疹病毒生物学的一种模式病毒。此外,由于该病毒具有感染突触连接神经元的显著倾向,被用作神经通路的示踪剂。我国虽然在根除PRV上取得了很大进展,但在许多国家仍然是一个地方性问题。现从PRV的最新研究技术、感染动物神经系统的致病机制以及功能应用3个方面进行综述。
Pseudorabies virus(PRV)is the pathogen of pigs,which has caused devastating diseases and economic losses all over the world.Because of the neurophilic nature of the virus,it has aroused great interest from virologists and neurobiologists.At present,PRV has become a model virus for the study of herpesvirus biology.In addition,because the virus has a significant tendency to infect synaptic junction neurons,it is used as a tracer of neural pathways.Although China has made great progress in eradicating PRV,it is still a local problem in many countries.This article will review the latest research technology of PRV,the pathogenic mechanism of infection of animal nervous system and its functional application.
作者
杨冰洁
罗国栋
甘玲
YANG Bing-jie;LUO Guo-dong;GAN Ling(College of Animal Science,Southwest University,Chongqing 402460,China)
出处
《中国兽医学报》
CAS
CSCD
北大核心
2020年第6期1253-1257,共5页
Chinese Journal of Veterinary Science
基金
中央高校基本业务费专项资金资助项目(XDJK-2019D014)。
关键词
伪狂犬病病毒
神经系统
致病机制
神经示踪
pseudorabies virus(PRV)
nervous system
pathogenic mechanism
neural tracing
