孕晚期B族链球菌感染88例临床分析

Clinical analysis of 88 cases of group B streptococcus infection in late pregnancy

目的探讨孕晚期孕妇B族链球菌感染的发生情况、治疗及对妊娠结局的影响。方法选取2017年9月至2019年8月在珠海市斗门区妇幼保健院治疗的88例孕晚期B族链球菌感染孕妇作为阳性组,同时,选取同期无B族链球菌感染孕妇88例,作为健康对照组,对两组孕妇的临床资料进行回顾性调查分析。结果年龄≥35岁、体质量≥25 kg/m^2、流产史、阴道炎、糖尿病是B族链球菌阳性的危险因素(P<0.05);B族链球菌对头孢呋辛、头孢吡肟、万古霉素敏感性可达到100%,对红霉素、克林霉素敏感性较低;B族链球菌阳性孕妇不良妊娠结局发生率明显高于健康对照组(P<0.05)。结论B族链球菌感染对妊娠结局危害较大,应对存在相关危险因素的孕妇进行重点筛查,并使用敏感性高的抗菌药物,提高治疗效果。

Objective To investigate the occurrence,treatment and the effect on pregnancy outcome of group B streptococcus infection in late pregnancy.Methods From September 2017 to August 2019,88 pregnant women with group B streptococcal infection in the third trimester were selected as the positive group.Meanwhile,88 pregnant women without group B streptococcal infection in the same period were selected as the healthy control group,and the clinical data of the two groups were analyzed.Results Age≥35 years old,weight≥25 kg/m^2,abortion history,vaginitis and diabetes mellitus were the risk factors of group B streptococcus(P<0.05);the sensitivity of group B streptococcus to cefuroxime,cefepime and vancomycin was 100%,and the sensitivity to erythromycin and clindamycin was low;the incidence of adverse pregnancy outcome of group B Streptococcus positive pregnant women was significantly higher than that of healthy control group(P<0.05).Conclusions Group B streptococcal infection is harmful to pregnancy outcome.It is necessary to screen pregnant women with related risk factors,and use antibiotics with high sensitivity to improve the treatment effect.