miR-21介导的TGF-β/Smad通路在子宫内膜样癌发病中的作用

子宫内膜样癌的发病机制尚不明确。TGF-β/Smad信号通路可能参与了子宫内膜样癌形成的多个过程。miR-21因在肿瘤侵袭转移中的调节作用而倍受重视。miR-21是否与TGF-β/Smad信号通路相关,是否通过该通路参与子宫内膜样癌的发生,其在发病机制中发挥怎样的作用以及通过调控miR-21能否成为子宫内膜样癌治疗的新策略,以上问题都需要进一步研究证实。本文将围绕上述问题进行综述。

The pathogenesis mechanism of endometrioid endometrial cancer(EEC)is not clear yet.TGF-β/Smad signaling pathway may participate in EEC formation process.miR-21 is concerned about the important role in the regulation of invasion and metastasis pathway in multiple organ tumor disease.It is need the further study to confirm whether miR-21 is associated with the TGF-β/Smad signaling pathway,whether it is involved in the pathogenesis of EEC through this pathway,the role of miR-21 in the pathogenesis of EEC,and whether regulation of miR-21 could become a new therapy strategy for EEC.A literature review will be made in this paper with the focus on the above issues.