血清25(OH)D,SOD,Hcy,hs-CRP及脂类水平检测与高血压病的关系研究

Study on the Relationship between the Levels of Serum 25(OH)D,SOD,Hcy,hsCRP and Lipids and Hypertension

目的探讨25羟维生素D[25(OH)D]、超氧化物歧化酶(SOD)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)及脂类指标与高血压的关系。方法采用病例对照研究方法,选取2017年1月~2019年7月期间入住聊城市第三人民医院心内科的高血压患者220例及40例年龄匹配的查体健康者。采用免疫比浊法检测25(OH)D,hs-CRP,循环酶法检测Hcy,比色法检测SOD,同时检测两组总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平。运用logistic回归模型评价与高血压相关的风险因子,受试者工作曲线(ROC)预测各指标在高血压诊治中的价值。结果观察组25(OH)D,HDL-C显著低于对照组,差异有统计学意义(Z=-3.018,-3.838,均P<0.01);观察组Hcy显著高于对照组,差异有统计学意义(Z=-3.378,P<0.01);logistic回归分析25(OH)D,Hcy,HDL-C是评估高血压的风险因素,OR值分别为1.070,0.876和9.160。ROC曲线显示,25(OH)D,Hcy和HDL-C诊断高血压的曲线下面积(AUC)分别为0.650,0.668和0.691,最佳界值为20.61,13.41和1.36。结论血清25(OH)D,HDL-C和Hcy表达是高血压诊治中的风险因子。

Objective To investigate the relationship between the levels 25 hydroxyvitamin D[25(OH)D],superoxide dismutase(SOD),homocysteine(Hcy),hypersensitive C-reactive protein(hs-CRP),lipid index and hypertension.Methods A case-control study were conducted,220 cases of hypertensive patients and 40 cases of age-matched healthy subjects were selected from the Department of Cardiology of the Third People’s Hospital of Liaocheng from January 2017 to July 2019.The levels of 25(OH)D,hsCRP,Hcy,SOD,TC,TG,HDL-C and LDL-C were measured by immunoturbidimetry and colorimetry,respectively.Logistic regression model was used to evaluate the risk factors related to hypertension,and ROC curve was used to predict the value of each index in the diagnosis and treatment of hypertension.Results 25(OH)-D and HDL-C in the observation group were significantly lower than those in the control group,and the difference was statistically significant(Z values were-3.018,-3.838,all P<0.01).Hcy in the observation group was significantly higher than that in the control group,and the difference was statistically significant(Z=-3.378,P<0.01).25(OH)D,Hcy and HDL-C in the logistic regression analysis were risk factors for hypertension,or values were 1.070,0.876 and 9.160,respectively.ROC curve showed that AUC of 25(OH)D,Hcy and HDL-C was 0.650,0.668 and 0.691,respectively,and the best boundary value was 20.61,13.41 and 1.36,respectioely.Conclusion The expression of serum 25(OH)VD,HDL-C and Hcy are risk factors in the diagnosis and treatment of hypertension.