冠心病患者血清补体C1q与hs-CRP水平监测的相关临床价值探讨

Discussion the clinical value of serum complement C1q and hs-CRP in patients with coronary heart disease

目的探讨血清补体C1q、超敏C反应蛋白(hs-CRP)在冠心病患者中的变化及其临床意义。方法选取就诊的210例患者,其中急性心肌梗死组49例,不稳定型心绞痛组52例,稳定型心绞痛组54例,对照组55例。采用免疫透射比浊法检测血清补体C1q水平,采用乳胶增强免疫法检测血清hs-CRP水平。结果急性心肌梗死组、不稳定型心绞痛组、稳定型心绞痛组患者补体C1q、hs-CRP水平均高于对照组(P<0.05),急性心肌梗死组患者血清补体C1q、hs-CRP水平高于不稳定型心绞痛组(P<0.05),不稳定型心绞痛组血清补体C1q、hs-CRP水平高于稳定型心绞痛组(P<0.05),稳定型心绞痛组补体C1q、hs-CRP水平高于对照组(P<0.05)。结论冠心病患者血清补体C1q、hs-CRP水平明显升高,且随着严重程度进一步升高。

Objective To investigate the changes of serum complement C1q and hs-CRP in patients with coronary heart disease and their clinical significance.Methods A total of 210 patients were selected,including 49 cases with acute myocardial infarction,52 cases with unstable angina,54 cases with stable angina,55 cases in the control group.The levels of serum complement C1q were detected by the immunoturbidimetry method,and the levels of serum hs-CRP was detected by the latex enhanced immune method.Results The levers of serum complement C1q and hs-CRP in patients with acute myocardia infarction,unstable angina pectoris and stable angina pectors were higher than those control group(P<0.05).The levels of serum complement C1q and hs-CRP in patients with acute myocardia infarction were higher than those with unstable angina pectoris(P<0.05).The levers of serum complement C1q and hs-CRP in patients with unstable angina pectoris were higher than those with stable angina pectors(P<0.05).Conclusion The levers of serum complement C1q and hs-CRP in patients with coronary heart disease increased significantly,and further increased with the severity.