美罗培南结合纤支镜肺泡灌洗对重症肺部感染患者炎症指标及血气指标的影响

The Effect of Meropenem Combined with Bronchoscopic Alveolar Lavage on Inflammation Indicators and Blood Gas Indicators in Patients with Severe Pulmonary Infection

目的探讨美罗培南结合纤支镜肺泡灌洗对重症肺部感染患者炎症指标及血气指标的影响。方法将我院2017年3月至2019年2月收治的124例重症肺部感染患者随机分为两组各62例,对照组采用美罗培南治疗,观察组采用美罗培南结合纤支镜肺泡灌洗治疗,比较两组治疗前与治疗14 d后的炎症指标(IL-8、 TNF-α、 hs-CRP)及血气指标(SaO2、 PaO2、 PaCO2)。结果治疗前,两组的IL-8、 TNF-α、 hs-CRP、 SaO2、 PaO2、 PaCO2水平比较,差异无统计学意义(P>0.05);治疗后,观察组的IL-8、 TNF-α、 hs-CRP、 PaCO2水平均显著低于对照组, SaO2、 PaO2水平均显著高于对照组(P <0.05)。结论美罗培南结合纤支镜肺泡灌洗能够有效改善重症肺部感染患者的炎症指标和血气指标。

Objective To explore the effect of meropenem combined with bronchoscopic alveolar lavage on inflammation indicators and blood gas indicators in patients with severe pulmonary infection.Methods 124 patients with severe pulmonary infection admitted to our hospital from March 2017 to February 2019 were randomly divided into two groups,with 62 cases in each group.The control group was treated with meropenem,and the observation group was treated with meropenem combined with bronchoscopic alveolar lavage.Before treatment and after treatment for 14 days,the inflammation indicators(IL-8,TNF-α,hs-CRP)and blood gas indicators(SaO2,PaO2,PaCO2)were compared between two groups.Results Before treatment,no statistical difference was found between two groups in the levels of IL-8,TNF-α,hs-CRP,SaO2,PaO2 and PaCO2(P>0.05);After treatment,the levels of IL-8,TNF-α,hs-CRP and PaCO2 of observation group were significantly lower than those of control group,and the levels of SaO2 and PaO2 were significantly higher than those of control group(P<0.05).Conclusions Meropenem combined with bronchoscopic alveolar lavage can effectively improve the inflammation indicators and blood gas indicators of patients with severe pulmonary infection.